protein 678 words KG: VPS4 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

VPS4 Protein

🔬 Protein Info
Gene SymbolVPS4
FunctionVPS4 (Vacuolar Protein Sorting 4 Homolog) is an AAA+ ATPase that functions in the final stages of multivesicular body (MVB) sorting and autophagy
Primary Expressionneuronal tissues
Amino Acids437 aa
UniProt IDVPS4A
GeneCardsVPS4
Human Protein AtlasVPS4
ApproachStatus
VPS4 activatorsResearch
ESCRT modulatorsPreclinical
Gene therapyResearch
Associated Diseasesneurodegeneration
InteractionsCHMP2B, CHMP4B, CHMP7, VPS4A, ALS, Ras
KG Connections35 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Lysosomal Membrane Repair Enhancement
Score: 0.45
Extracellular Vesicle Biogenesis Modulation
Score: 0.34
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (8)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (9)

Proteins
index · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
CHMP7 mutations cause hereditary spastic paraplegia
gene · KG edge: interacts_with
CHMP4B — Charged Multivesicular Body Protein 4B
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

VPS4 interacts_with CHMP2B
VPS4 interacts_with CHMP4B
VPS4 interacts_with CHMP7
VPS4 interacts_with VPS4A
VPS4 inhibits VPS4A
VPS4 activates ALS
VPS4 expressed_in Neuron
VPS4 activates Als
VPS4 activates Neuron
VPS4 activates Ras