gene 797 words KG: CHMP7 2026-03-27
kind:genesection:genesstate:published
Contents

CHMP7 mutations cause hereditary spastic paraplegia

🧬 Gene Info
Gene SymbolCHMP7
Full NameCharged Multivesicular Body Protein 7
Chromosome8p21.3
Functionis a unique hybrid ESCRT-III/CHMP4 family member with distinct functions in both the endosomal system and nuclear envelope maintenance.
PathwaysCRISPR-Cas, oxidative stress response
UniProt ID[Q9Y3X5](https://www.uniprot.org/uniprot/Q9Y3X5)
Ensembl IDENSG00000165457
GeneCardsCHMP7
Human Protein AtlasCHMP7
Associated DiseasesALS, Infection, Inflammation, Sepsis
InteractionsCHMP2B, CHMP4B, SMN, VPS4, Rb, VPS4A
KG Connections107 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.42
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.53
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Lysosomal Membrane Repair Enhancement
Score: 0.45

Related Analyses (6)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: causes
Packard Center for ALS Research
institution · KG edge: activates
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
CHMP4B — Charged Multivesicular Body Protein 4B
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

CHMP7 activates CHMP2B
CHMP7 associated_with CD8
CHMP7 associated_with MAP1LC3B
CHMP7 associated_with PRKACA
CHMP7 associated_with NLRC4
CHMP7 associated_with CD4
CHMP7 associated_with GCLM
CHMP7 expressed_in STMN2
CHMP7 associated_with Nuclear Pore Complex
CHMP7 modulates TDP-43