technology 1,805 words KG: Biomarker 2026-03-23
kind:technologysection:technologiesstate:published
Contents

Artificial Intelligence in Neurodegeneration Research

Knowledge Graph

Related Hypotheses (30)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 139 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 139 hypotheses
VEGF Signaling and Cerebral Angiogenesis in Neurodegene
mechanism · Pages share 139 hypotheses
Vagus Nerve Pathway in Neurodegeneration
mechanism · Pages share 139 hypotheses

Knowledge Graph (11 edges)

Biomarker biomarker_for Thyroid Cancer
Biomarker correlates_with Disease Trajectory
Biomarker biomarker_for Septic Shock
Biomarker involved_in Sepsis Diagnosis
Biomarker biomarker_for Prostate Cancer
Biomarker biomarker_for Aging
Biomarker biomarker_for Amyotrophic Lateral Sclerosis
Biomarker biomarker_for Frontotemporal Dementia
Biomarker biomarker_for Alzheimer's Disease
HMGB1 biomarker_for Biomarker
\n\n[@neurowiki2026]: https://neurowiki.org (NeuroWiki Editorial Board)\n\n## Background\n\nThe study of Artificial Intelligence In Neurodegeneration Research has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.\n\nHistorical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.\n\n## References\n\n1. Unknown, NeuroWiki. (2026). Reference. Retrieved from NeuroWiki.## External Links (2026)"; const refs = {"neurowiki2026": {"title": "NeuroWiki. (2026). Reference. Retrieved from NeuroWiki.## External Links", "year": 2026}}; const citationOrder = []; const citationMap = {}; // refs_json is the authoritative source for reference metadata. // Replace [@key] markers with superscript HTML BEFORE markdown-it renders. // Consume preceding whitespace so citations sit flush against text (Wikipedia style). const hasRefs = refs && Object.keys(refs).length > 0; if (hasRefs) { raw = raw.replace(/\s*\[@([a-zA-Z0-9_]+)\]/g, function(match, key) { if (!refs[key]) return match; if (!(key in citationMap)) { citationOrder.push(key); citationMap[key] = citationOrder.length; } const num = citationMap[key]; const r = refs[key]; const tip = (r.authors || '') + ' (' + (r.year || '') + ')'; return '' + '' + '[' + num + ']'; }); } const contentEl = document.getElementById('wiki-content'); contentEl.innerHTML = md.render(raw); // --- Build References section from refs_json (authoritative source) --- if (citationOrder.length > 0) { // Remove any existing reference-like sections (we regenerate from refs_json) contentEl.querySelectorAll('h2').forEach(h2 => { const t = h2.textContent.trim().toLowerCase(); if (t === 'references' || t.startsWith('references (') || t === 'key publications' || t === 'additional references' || t === 'key references' || t === 'selected publications' || t === 'research publications') { // Remove the heading and all content until next h1/h2 let sib = h2.nextElementSibling; while (sib && !sib.matches('h1,h2')) { const next = sib.nextElementSibling; sib.remove(); sib = next; } h2.remove(); } }); const refsSection = document.createElement('div'); refsSection.id = 'references-section'; const h2 = document.createElement('h2'); h2.textContent = 'References'; refsSection.appendChild(h2); const ol = document.createElement('ol'); ol.style.cssText = 'padding-left:1.5rem;font-size:0.9rem;line-height:1.7;color:#ccc'; citationOrder.forEach((key, i) => { const r = refs[key]; const li = document.createElement('li'); li.id = 'ref-' + (i + 1); li.style.cssText = 'margin-bottom:0.6rem;padding-left:0.3rem'; let h = ''; if (r.authors) h += '' + r.authors + ' '; if (r.year) h += '(' + r.year + ') '; if (r.title) { const t = r.title.replace(/^'|'$/g, '').replace(//g,'>'); const url = r.doi ? 'https://doi.org/' + r.doi : r.pmid ? 'https://pubmed.ncbi.nlm.nih.gov/' + r.pmid + '/' : r.url || ''; if (url) h += '' + t + '. '; else h += '' + t + '. '; } if (r.journal) h += '' + r.journal + ''; if (!r.title && (r.doi || r.pmid)) { const url = r.doi ? 'https://doi.org/' + r.doi : 'https://pubmed.ncbi.nlm.nih.gov/' + r.pmid + '/'; h += ' ' + (r.doi ? 'DOI' : 'PubMed') + ''; } li.innerHTML = h; ol.appendChild(li); }); refsSection.appendChild(ol); contentEl.appendChild(refsSection); } // --- Rich citation hover popover --- (function() { const popover = document.createElement('div'); popover.id = 'cite-popover'; popover.style.cssText = 'position:absolute;display:none;background:#1a1a2e;color:#e0e0e0;' + 'border:1px solid rgba(79,195,247,0.35);border-radius:8px;padding:0.75rem 1rem;' + 'font-size:0.82rem;max-width:440px;z-index:10000;pointer-events:none;' + 'box-shadow:0 6px 20px rgba(0,0,0,0.5);line-height:1.5;opacity:0;' + 'transition:opacity 0.12s ease;'; document.body.appendChild(popover); let showTimer = null, hideTimer = null, currentKey = null; function showPopover(a, key) { if (key === currentKey) return; currentKey = key; const r = refs[key] || {}; const num = a.textContent.replace(/[\[\]]/g,''); const url = r.pmid ? 'https://pubmed.ncbi.nlm.nih.gov/' + r.pmid + '/' : r.doi ? 'https://doi.org/' + r.doi : ''; let html = '
[' + num + '] '; if (r.authors) html += r.authors.split(',')[0].trim() + ' et al.'; if (r.year) html += ' (' + r.year + ')'; if (r.journal) html += ' · ' + r.journal + ''; html += '
'; if (r.title) { const clean = r.title.replace(/^["']|["']$/g,'').replace(//g,'>'); html += '
' + clean + '
'; } if (r.claim) { html += '
' + '↳ ' + r.claim.replace(//g,'>') + '
'; } if (r.excerpt) { html += '
“' + r.excerpt.replace(//g,'>') + '”
'; } // Show figure thumbnail if the citation references a paper figure if (r.figure_ref || r.figure_artifact_id) { const figLabel = r.figure_ref || 'Figure'; const figCaption = (r.figure_caption || '').replace(//g,'>'); html += '
' + '
📊 ' + figLabel + '
'; if (figCaption) { html += '
' + figCaption.substring(0, 200) + (figCaption.length > 200 ? '…' : '') + '
'; } html += '
'; } if (url) { html += '
' + '' + (r.pmid ? 'PubMed' : 'DOI') + ' →
'; } popover.style.pointerEvents = 'auto'; const rect = a.getBoundingClientRect(); popover.style.display = 'block'; const pw = popover.offsetWidth; const left = Math.max(8, Math.min(rect.left + window.scrollX, window.innerWidth - pw - 8 + window.scrollX)); popover.style.left = left + 'px'; popover.style.top = (rect.bottom + window.scrollY + 6) + 'px'; popover.style.opacity = '1'; } function hidePopover() { currentKey = null; popover.style.opacity = '0'; setTimeout(function() { if (!currentKey) popover.style.display = 'none'; }, 120); } contentEl.addEventListener('mouseover', function(e) { const a = e.target.closest('a.ref-link'); if (!a) return; const key = a.getAttribute('data-ref-key'); if (!key || !refs[key]) return; clearTimeout(hideTimer); showTimer = setTimeout(function() { showPopover(a, key); }, 150); }); contentEl.addEventListener('mouseout', function(e) { const a = e.target.closest('a.ref-link'); if (!a) return; clearTimeout(showTimer); hideTimer = setTimeout(hidePopover, 300); }); popover.addEventListener('mouseover', function() { clearTimeout(hideTimer); }); popover.addEventListener('mouseout', function() { hideTimer = setTimeout(hidePopover, 300); }); })(); // Convert mermaid code blocks to divs (wiki.js html-mermaid approach) // markdown-it wraps all highlight output in
, breaking mermaid.
    contentEl.querySelectorAll('pre > code.language-mermaid').forEach(code => {
        const pre = code.parentElement;
        const div = document.createElement('div');
        div.className = 'mermaid';
        div.textContent = code.textContent;
        pre.replaceWith(div);
    });

    // Dark mode fix: strip light-mode inline backgrounds from infoboxes/divs
    contentEl.querySelectorAll('.infobox, [class*="infobox"], [class*="quick-ref"]').forEach(el => {
        el.style.background = '#151525';
        el.style.borderColor = 'rgba(79,195,247,0.2)';
        el.style.color = '#e0e0e0';
        el.style.borderRadius = '8px';
        // Fix child elements too
        el.querySelectorAll('*').forEach(child => {
            if (child.style.color && (child.style.color.includes('#000') || child.style.color.includes('#333') || child.style.color.includes('rgb(0')))
                child.style.color = '#e0e0e0';
            if (child.style.background && (child.style.background.includes('#f') || child.style.background.includes('#e') || child.style.background.includes('#d') || child.style.background.includes('white')))
                child.style.background = 'transparent';
            if (child.style.borderColor && (child.style.borderColor.includes('#d') || child.style.borderColor.includes('#c')))
                child.style.borderColor = 'rgba(255,255,255,0.08)';
        });
    });

    // Also catch any div with light inline background that isn't classed
    contentEl.querySelectorAll('div[style]').forEach(el => {
        const bg = el.style.background || el.style.backgroundColor || '';
        if (bg.match(/#f[0-9a-f]|#e[0-9a-f]|#d[0-9a-f]|white|#fff/i)) {
            el.style.background = '#151525';
            el.style.borderColor = 'rgba(79,195,247,0.2)';
            el.style.color = '#e0e0e0';
            el.style.borderRadius = '8px';
        }
    });

    // Style blockquotes with classes
    contentEl.querySelectorAll('blockquote').forEach(bq => {
        const t = bq.textContent.toLowerCase();
        if (t.startsWith('warning') || t.startsWith('caution')) bq.classList.add('is-warning');
        else if (t.startsWith('danger') || t.startsWith('error')) bq.classList.add('is-danger');
        else if (t.startsWith('success') || t.startsWith('tip')) bq.classList.add('is-success');
    });

    // Syntax highlighting
    Prism.highlightAllUnder(contentEl);

    // Mermaid diagrams — initialize then render all blocks
    mermaid.initialize({ theme: 'base', startOnLoad: false, securityLevel: 'loose', flowchart: { htmlLabels: true, useMaxWidth: false, wrappingWidth: 200, padding: 15 }, themeVariables: { primaryColor: '#1e3a4a', primaryTextColor: '#e0e0e0', primaryBorderColor: '#4fc3f7', lineColor: '#4fc3f7', secondaryColor: '#1a3a2a', tertiaryColor: '#2a1a3a', secondaryTextColor: '#e0e0e0', tertiaryTextColor: '#e0e0e0', clusterBorder: '#4fc3f7', edgeLabelBackground: '#151525', clusterBkg: '#12122a', nodeBorder: '#4fc3f7', mainBkg: '#1e3a4a', nodeTextColor: '#e0e0e0', background: '#151525', fontSize: '14px', fontFamily: 'system-ui' } });
    // Dark-mode color map: rewrite light/bright fills to dark equivalents
    const _dm = {
        // Light blues
        '#e1f5fe':'#0d2137','#e3f2fd':'#0d2137','#bbdefb':'#0d2137',
        '#4fc3f7':'#0d3b54','#03a9f4':'#01579b','#b3e5fc':'#0d2137',
        // Light oranges / yellows
        '#fff3e0':'#3e2200','#ffe0b2':'#3e2200','#ffcc80':'#3e2200',
        '#ffd54f':'#3a3000','#ffca28':'#3a3000','#ffc107':'#3a3000',
        '#fff9c4':'#3a3000','#ffecb3':'#3a3000','#fff8e1':'#3a3000',
        '#ff9800':'#4e2d00','#ffb74d':'#3e2200','#ff8a65':'#4a1500',
        // Light reds / pinks
        '#ffcdd2':'#3b1114','#fce4ec':'#3b1114','#ffebee':'#3b1114',
        '#ef5350':'#7f1d1d','#f44336':'#7f1d1d','#e53935':'#7f1d1d',
        '#ef9a9a':'#5c1515','#ff6b6b':'#7f1d1d','#ff6666':'#7f1d1d',
        '#f99':'#5c1515','#ffb6c1':'#5c1525',
        // Light greens
        '#c8e6c9':'#0e2e10','#e8f5e9':'#0e2e10','#a5d6a7':'#0e2e10',
        '#81c784':'#1b4d1e','#4caf50':'#1b5e20','#66bb6a':'#1b5e20',
        '#8bc34a':'#33691e','#9f9':'#0e2e10',
        // Light purples
        '#f3e5f5':'#2a0e3a','#e8eaf6':'#2a0e3a',
        '#ce93d8':'#4a1a6b','#b39ddb':'#311b6b',
        '#99f':'#2a0e3a','#bbf':'#2a1a5a',
        // Greys / browns
        '#efebe9':'#2a2320','#d7ccc8':'#2a2320',
        '#e0e0e0':'#252535','#f5f5f5':'#252535','#b0bec5':'#263238',
        // Already-dark fills: keep as-is (no entry needed)
    };
    function _darkify(txt) {
        // Replace light/bright fill colors with dark equivalents, fix text color
        return txt.replace(/fill:#[0-9a-fA-F]{3,6}/gi, m => {
            const c = m.slice(5).toLowerCase();
            const dk = _dm['#'+c] || _dm[c];
            return dk ? 'fill:'+dk : m;
        }).replace(/,color:#000/g,',color:#e0e0e0')
          .replace(/,color:#333/g,',color:#ddd')
          .replace(/color:#000/g,'color:#e0e0e0')
          .replace(/color:#333/g,'color:#ddd');
    }
    const mermaidEls = contentEl.querySelectorAll('.mermaid');
    if (mermaidEls.length > 0) {
        // Render each mermaid block individually so one failure doesn't break all
        for (const el of mermaidEls) {
            try {
                const id = 'mermaid-' + Math.random().toString(36).substr(2, 9);
                const { svg } = await mermaid.render(id, _darkify(el.textContent.trim()));
                el.innerHTML = svg;
                if (window.SciDexMermaid) window.SciDexMermaid.enhanceElement(el);
                // Fix foreignObject clipping: measure actual content and resize
                el.querySelectorAll('foreignObject').forEach(fo => {
                    const div = fo.querySelector('div');
                    if (!div) return;
                    const actual = div.scrollHeight || div.offsetHeight;
                    const foH = parseFloat(fo.getAttribute('height') || 0);
                    if (actual > foH + 2) {
                        const diff = actual - foH + 8;
                        fo.setAttribute('height', actual + 8);
                        // Also grow the parent node rect/shape
                        const node = fo.closest('.node,.label');
                        if (node) {
                            const rect = node.querySelector('rect,polygon,circle,ellipse');
                            if (rect && rect.getAttribute('height')) {
                                rect.setAttribute('height', parseFloat(rect.getAttribute('height')) + diff);
                            }
                        }
                    }
                });
            } catch(e) {
                el.innerHTML = '
Diagram error: ' + e.message + '
'; } } } // Build TOC from rendered headings. // markdown-it-anchor adds slug-based IDs at render time using _slugify. // The TOC just reads h.id. For content with manually-authored anchor // links (e.g. [Parkinson's](#old-slug)), we also build a map and // create secondary anchors so both old and new slugs work. const _anchorMap = {}; contentEl.querySelectorAll('a[href^="#"]').forEach(a => { const frag = a.getAttribute('href').slice(1); const text = a.textContent.trim().toLowerCase(); if (frag && text) _anchorMap[text] = frag; }); const tocEl = document.getElementById('toc'); const headings = contentEl.querySelectorAll('h1,h2,h3,h4'); headings.forEach((h, i) => { // markdown-it-anchor should have set h.id already; fall back to _slugify if (!h.id) h.id = _slugify(h.textContent) || ('heading-' + i); const id = h.id; // If content has a different anchor slug for this heading, create a // hidden anchor so BOTH the canonical slug AND the old slug work. const hText = h.textContent.trim().toLowerCase(); const oldSlug = _anchorMap[hText]; if (oldSlug && oldSlug !== id) { const span = document.createElement('span'); span.id = oldSlug; h.parentNode.insertBefore(span, h); } const a = document.createElement('a'); a.href = '#' + id; a.textContent = h.textContent; if (h.tagName === 'H3' || h.tagName === 'H4') a.classList.add('toc-h3'); a.onclick = function(e) { e.preventDefault(); h.scrollIntoView({ behavior: 'smooth', block: 'start' }); history.replaceState(null, '', '#' + id); }; tocEl.appendChild(a); }); // On page load, scroll to the anchor if present in URL if (window.location.hash) { const target = document.getElementById(window.location.hash.slice(1)); if (target) setTimeout(() => target.scrollIntoView({ block: 'start' }), 100); } // Highlight current TOC item on scroll const tocLinks = tocEl.querySelectorAll('a'); const observer = new IntersectionObserver(entries => { entries.forEach(entry => { if (entry.isIntersecting) { tocLinks.forEach(l => l.classList.remove('active')); const active = tocEl.querySelector('a[href="#' + entry.target.id + '"]'); if (active) active.classList.add('active'); } }); }, { rootMargin: '-80px 0px -80% 0px' }); headings.forEach(h => observer.observe(h)); })();