concept

DISEASE-ASSOCIATED MICROGLIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DISEASE-ASSOCIATED MICROGLIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

370Connections

6Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

DISEASE-ASSOCIATED MICROGLIA is a concept in neurodegeneration research. Key relationships include: activates, associated with, expressed in. Associated with Aging, Als, Alzheimer. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	DISEASE-ASSOCIATED MICROGLIA
Summary	Page for Disease-Associated Microglia
Key Genes/Proteins	TREM2, MICROGLIA, MYELIN
Related Diseases	Neurodegeneration, Alzheimer, NEURODEGENERATIVE DISEASES, Als, Aging

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DISEASE_ASSOCIATED_MICROGLIA["DISEASE-ASSOCIATED MICROGLIA"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"activates"| Ms["Ms"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"activates"| Tumor["Tumor"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Inflammation["Inflammation"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Alzheimer["Alzheimer"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Aging["Aging"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Tauopathy["Tauopathy"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"expressed in"| Dementia["Dementia"]
    DISEASE_ASSOCIATED_MICROGLIA -->|"target for"| Als["Als"]
    TREM2["TREM2"] -->|"regulates"| DISEASE_ASSOCIATED_MICROGLIA
    MICROGLIA["MICROGLIA"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    CYTOKINES["CYTOKINES"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    TNF["TNF"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    TNFR1["TNFR1"] -->|"activates"| DISEASE_ASSOCIATED_MICROGLIA
    AGING["AGING"] -->|"expressed in"| DISEASE_ASSOCIATED_MICROGLIA
    BCL2["BCL2"] -->|"expressed in"| DISEASE_ASSOCIATED_MICROGLIA

Outgoing (250)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.95
Alzheimer	activates	disease	0.85
NEURODEGENERATIVE DISEASES	implicated_in	disease	0.80
MICROGLIA	activates	gene	0.80
MICROGLIA	associated_with	gene	0.80
Als	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Alzheimer	expressed_in	disease	0.75
Alzheimer	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Als	activates	disease	0.75
Neuroinflammation	activates	disease	0.75
Inflammation	activates	disease	0.75
MYELIN	activates	gene	0.70
ALZHEIMER'S DISEASE	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70
TREM2	causes	gene	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Tauopathy	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Hypertension	activates	disease	0.65
Neuropathy	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Dementia	activates	disease	0.65
Tauopathy	activates	disease	0.65
Als	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Ms	causes	disease	0.65
Cancer	causes	disease	0.65
Aging	causes	disease	0.65
ALS	associated_with	disease	0.65
Autism	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Lewy Body	activates	disease	0.65
Epilepsy	activates	disease	0.65
Cancer	associated_with	disease	0.65

Incoming (120)

Source	Relation	Type	Str
TREM2	regulates	gene	0.90
TREM2	activates	gene	0.80
NEURODEGENERATION	activates	gene	0.80
TAU	activates	gene	0.80
CYTOKINES	activates	gene	0.70
TREM2	associated_with	gene	0.70
NEURODEGENERATION	associated_with	gene	0.70
NEURODEGENERATIVE DISEASES	associated_with	gene	0.70
ALZHEIMER	activates	gene	0.70
AMYLOID	activates	gene	0.70
TAU PATHOLOGY	activates	gene	0.70
ALZHEIMER	expressed_in	gene	0.70
MICROGLIA	targets	cell_type	0.65
TREM2	exacerbates	gene	0.65
MICROGLIA	biomarker_for	cell_type	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
TNFR1	activates	gene	0.60
AGING	expressed_in	gene	0.60
BCL2	expressed_in	gene	0.60
MICROGLIA	associated_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
BCL2 FAMILY	expressed_in	gene	0.60
AGING	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
APOE	associated_with	gene	0.60
CLN3	therapeutic_target	gene	0.60
DMSO	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ASTROCYTES	associated_with	gene	0.60
CXCL10	associated_with	gene	0.60
TAU PATHOLOGY	therapeutic_target	gene	0.60
C1QA	associated_with	gene	0.60
TAU	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
DRD1	therapeutic_target	gene	0.60
GPNMB	therapeutic_target	gene	0.60
NLRP3	therapeutic_target	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
P2RY12	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
GAIN	activates	gene	0.60
STAT3	activates	gene	0.60

Targeting Hypotheses (6)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro	0.662	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri	0.515	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
Disease-Associated Microglia Metabolic Reprogramming	0.502	neurodegeneration	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop	0.493	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub	0.491	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul	0.485	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di

Mentioning Analyses (4)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PMID:41862445]	Qin J, Ma S, Wang J, Huang S, Luan J, He	Cell death & disease	2026
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis [PMID:41902795]	Gao C, Liu B, Zhang R, Tian J, Xin H	Toxicology mechanisms and meth	2026
NEDD8 promotes the ferritinophagy and ferroptosis of neurons in ischemic stroke [PMID:41662890]	Rao W, Huang Y, Li J, Chen Q, Sun J et a	J Stroke Cerebrovasc Dis	2026
Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892]	Lin D, Li K, Kuang W, Chen Z, Zhang M	World J Mens Health	2026
Deciphering sorafenib resistance in hepatocellular carcinoma via ferroptotic mec [PMID:41763496]	Che L, Zhu L, Zhou L, Zhou Y	Biochim Biophys Acta Rev Cance	2026
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis [PMID:41860570]	Chien Y, Xia R, Zhou D, Ai Y, Wu L et al	Hepatol Commun	2026
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579]	Wu K, Wang N, Zhao D, Wei W, Zhang W et	Zhejiang Da Xue Xue Bao Yi Xue	2026
Unraveling the impact of risk factors on the ferroptosis-Alzheimer's disease lin [PMID:41498558]	Singh P, Rath SL	Journal of Alzheimer's disease	2026
Resveratrol Alleviates Intervertebral Disc Degeneration by Targeting NCOA4-Media [PMID:41873334]	Song C, Wu X, Chen C, Shen B, He Y, Liu	Drug design, development and t	2026
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026
Acteoside alleviates sepsis-induced acute lung injury by activating the Nrf2 pat [PMID:41895086]	Wang Y, Zhang W, Zhang M, Zhu Y, Wang W,	Tissue & cell	2026
Ferroptosis and microglial polarization in retinal vein occlusion: pathological [PMID:41924362]	Xu J, Sun M, Wang C, Ju P, Guan XD, Xie	International journal of ophth	2026
Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates. [PMID:41819088]	Liu L, Zheng Z, You W, Yang P, Wen Y et	Cell Metab	2026
LPCAT3 deficiency Drives phospholipid remodeling and mitochondrial oxidative dys [PMID:41951050]	Shao G, Ye C, Sun C, Pan J, Lu L et al.	J Adv Res	2026
Microglia, Trem2, and Neurodegeneration. [PMID:38769824]	Shi Q, Gutierrez RA, Bhat MA	Neuroscientist	2025
Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Am [PMID:40442550]	Wongjaikam S, Siengdee P, Somnus A, Govi	Neurotoxicity research	2025
Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzhei [PMID:40640358]	Zhu L, Zhou T, Wu L, Zhu X, Chen L, Zhan	Scientific reports	2025
Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathol [PMID:39510074]	["Zha Xu", "Liu Xicheng", "Wei Mengping"	Cell metabolism	2025
Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis [PMID:41394684]	Montesinos J, Yun TD, Salomón-Cruz ID, A	bioRxiv : the preprint server	2025
Danggui Shaoyao San ameliorates Alzheimer's disease by regulating lipid metaboli [PMID:40271063]	Gong K, Zhou S, Xiao L, Xu M, Zhou Y, Lu	Frontiers in pharmacology	2025

DISEASE-ASSOCIATED MICROGLIA

Understanding Entity Pages

Summary

Wiki Pages (21)