Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–50 of 161 pages matching "upr"

🏥 Progressive Supranuclear Palsy (PSP)KG

disease · 12,907 words · 21 hyp12 ana63 exp

⚙️ Unfolded Protein Response (UPR)KG

mechanism · 3,651 words · 41 hyp48 ana

⚙️ Disease Progression and Staging in Progressive Supranuclear PalsyKG

mechanism · 3,633 words · 12 hyp43 ana26 exp

🧪 FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear PalsyKG

clinical · 3,559 words · 14 hyp6 ana26 exp

⚙️ Mitochondrial Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 3,494 words · 41 hyp44 ana29 exp

Progressive Supranuclear Palsy (PSP) PathwayKG

mechanisms · 3,322 words · 13 hyp38 ana29 exp

🏥 Progressive Supranuclear PalsyKG

disease · 3,312 words · 14 hyp11 ana57 exp

🔬 Supramammillary NeuronsKG

cell · 3,160 words · 9 hyp16 ana5 exp

💊 Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)KG

therapeutic · 3,098 words · 142 hyp57 ana33 exp

🏥 Genetics of Progressive Supranuclear PalsyKG

disease · 3,094 words · 22 hyp13 ana47 exp

⚙️ Neuropathology of Progressive Supranuclear PalsyKG

mechanism · 3,085 words · 11 hyp34 ana28 exp

⚙️ Lysosomal Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 3,018 words · 24 hyp56 ana30 exp

Neural Circuits in Progressive Supranuclear PalsyKG

circuit · 2,799 words · 7 hyp4 ana28 exp

⚙️ Computational Models of Tau Propagation in Progressive Supranuclear PalsyKG

mechanism · 2,788 words · 17 hyp40 ana36 exp

💊 Progressive Supranuclear Palsy (PSP) Treatment GuideKG

therapeutic · 2,777 words · 11 hyp8 ana48 exp

⚙️ Brain Network Connectivity Changes in Progressive Supranuclear PalsyKG

mechanism · 2,753 words · 10 hyp39 ana23 exp

💊 Progressive Supranuclear Palsy (PSP) TreatmentKG

therapeutic · 2,746 words · 12 hyp12 ana32 exp

🧪 FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear PalsyKG

clinical · 2,720 words · 25 hyp11 ana34 exp

📊 Biomarkers for Progressive Supranuclear PalsyKG

biomarker · 2,622 words · 173 hyp58 ana33 exp

⚙️ ER Stress and Unfolded Protein Response in Parkinson's DiseaseKG

mechanism · 2,593 words · 80 hyp65 ana64 exp

🏥 Gender Differences in Progressive Supranuclear PalsyKG

disease · 2,584 words · 23 hyp24 ana45 exp

⚙️ Gait and Balance Disorders in Progressive Supranuclear PalsyKG

mechanism · 2,582 words · 3 hyp35 ana23 exp

📊 CSF Biomarkers for Corticobasal Syndrome and Progressive Supranuclear PalsyKG

biomarker · 2,568 words · 15 hyp11 ana133 exp

⚙️ Mitochondrial Complex I Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 2,494 words · 45 hyp45 ana26 exp

⚙️ Olfactory Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 2,476 words · 29 hyp49 ana26 exp

⚙️ Computational Tau Spreading Models in Progressive Supranuclear PalsyKG

mechanism · 2,468 words · 15 hyp39 ana33 exp

⚙️ Tau Propagation and Seeding in Progressive Supranuclear PalsyKG

mechanism · 2,464 words · 16 hyp39 ana22 exp

🧪 Neurologic Stem Cell Treatment Study for Progressive Supranuclear Palsy (NCT02795052)KG

clinical · 2,439 words · 15 hyp8 ana26 exp

⚙️ Progressive Supranuclear Palsy Treatment LandscapeKG

mechanism · 2,427 words · 15 hyp36 ana30 exp

⚙️ Vestibular Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 2,409 words · 16 hyp42 ana23 exp

⚙️ Neurotransmitter Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 2,317 words · 18 hyp39 ana41 exp

⚙️ Astrocytic Pathology in Progressive Supranuclear PalsyKG

mechanism · 2,308 words · 13 hyp42 ana22 exp

Progressive Supranuclear Palsy Neural CircuitKG

circuit · 2,289 words · 3 hyp3 ana22 exp

📊 Neuroimmune Biomarkers in Progressive Supranuclear PalsyKG

biomarker · 2,274 words · 14 hyp11 ana35 exp

⚙️ Synaptic Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 2,238 words · 28 hyp43 ana23 exp

ER Stress & UPR Therapeutics Investment LandscapeKG

investment · 2,220 words · 107 hyp54 ana25 exp

Eye Tracking and Saccade Testing in Progressive Supranuclear PalsyKG

diagnostic · 2,156 words · 9 hyp9 ana34 exp

🏥 Pupillary and Visual Dysfunction in Progressive Supranuclear PalsyKG

disease · 2,129 words · 3 hyp35 ana45 exp

⚙️ ER Stress and UPR Disease ComparisonKG

mechanism · 2,087 words · 64 hyp64 ana3 exp

⚙️ ER Stress and Unfolded Protein Response in 4R-TauopathiesKG

mechanism · 2,061 words · 77 hyp57 ana5 exp

⚙️ Selective Neuronal Vulnerability in Progressive Supranuclear PalsyKG

mechanism · 2,052 words · 37 hyp51 ana41 exp

⚙️ Oligodendroglial Involvement in Progressive Supranuclear PalsyKG

mechanism · 2,029 words · 12 hyp37 ana34 exp

⚙️ Tau Aggregate Specificity in Progressive Supranuclear PalsyKG

mechanism · 2,028 words · 28 hyp49 ana22 exp

⚙️ Speech and Swallowing Disorders in Progressive Supranuclear Palsy: Mechanisms and ManagementKG

mechanism · 2,011 words · 3 hyp36 ana24 exp

🔬 Unfolded Protein Response (UPR) NeuronsKG

cell · 1,998 words · 11 hyp17 ana1 exp

⚙️ Vascular and Endothelial Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 1,992 words · 29 hyp47 ana37 exp

⚙️ Environmental Risk Factors in Progressive Supranuclear PalsyKG

mechanism · 1,973 words · 7 hyp34 ana29 exp

🔬 Substantia Nigra Neurons in Progressive Supranuclear PalsyKG

cell · 1,959 words · 8 hyp12 ana30 exp

⚙️ Tau Aggregation Mechanisms in Progressive Supranuclear PalsyKG

mechanism · 1,912 words · 24 hyp49 ana26 exp

⚙️ Proteasome Dysfunction in Progressive Supranuclear PalsyKG

mechanism · 1,874 words · 41 hyp57 ana29 exp