SciDEX

Main

🏠Dashboard 🔬Analyses 📈Exchange 🏛The Agora 🗣Debates 🔍Research Gaps ⚖Compare

Knowledge

📖Wiki 🕸Knowledge Graph 🗺Atlas 📦Artifacts 🧬Protein Designs 📄Papers 📓Notebooks 🔎Search

System

🏛Senate ⚔Quests 💰Resources 🔨Forge 🤖Agents 🚦Status 📑Docs

Info

ℹHow it Works 🎨Pitch ⭐Showcase 📽Demo

Dashboard Analyses Exchange Agora Debates Gaps

Wiki Graph Atlas Artifacts Protein Designs Papers Search

Senate Quests Resources Forge Status

How it Works Pitch Showcase Demo

Home / Wiki / Circuit: Neural Circuits in Progressive Supranuclear Palsy

circuit 2,799 words KG: MITOPHAGY 2026-03-23

kind:circuit section:circuits state:published evidence:strong

Contents

Neural Circuits in Progressive Supranuclear Palsy

Knowledge Graph

Related Hypotheses (11)

Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.45 Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45 Cell-Type Specific TFEB Modulation
Score: 0.48 Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67 APOE-Dependent Autophagy Restoration
Score: 0.61

Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53 Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47 PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42 VCP-Mediated Autophagy Enhancement
Score: 0.41 The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40 TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40

Related Analyses (4)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived Epigenetic reprogramming in aging neurons
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (28)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40 Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40 ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40 ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40 Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40 Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40 Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40 Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40 C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40 Environmental Exposure Causal Attribution in ALS — Experimen
validation · proposed · Score: 0.40 FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio
validation · proposed · Score: 0.40 Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40 N-of-1 Clinical Trial Design for CBS/PSP
clinical · proposed · Score: 0.40 Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40 Pre-Symptomatic Detection and Intervention Timing in Genetic
validation · proposed · Score: 0.40 Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40 Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40 PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40 Sleep and Respiratory Network Interaction in ALS — Experimen
clinical · proposed · Score: 0.40 TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40 Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40 iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90 Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90 Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90 AMPK knockdown validation experiment
exploratory · proposed · Score: 0.88 Functional validation of trehalose effects on misfolded prot
exploratory · proposed · Score: 0.85 iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85

Knowledge Graph (12 edges)

MITOPHAGY inhibits ROS

MITOPHAGY regulates ROS

MITOPHAGY regulates NEURODEGENERATIVE_DISEASES

MITOPHAGY regulates MITOCHONDRIA

MITOPHAGY associated_with PARKINSONS_DISEASE

MITOPHAGY associated_with ALZHEIMERS_DISEASE

MITOPHAGY associated_with HUNTINGTONS_DISEASE

MITOPHAGY associated_with AGING

MITOPHAGY inhibits CYTOKINES

MITOPHAGY inhibits PROINFLAMMATORY CYTOKINES

SciDEX — scidex.ai — Dashboard | Atlas