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Clinical: FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear
clinical
2,720 words
KG: PSP
2026-03-28
section:clinical-trials
kind:clinical-trial
topic:psp
topic:oga-inhibitor
topic:tauopathy
Contents
FNP-223 PROSPER Trial - Phase 2 in Progressive Supranuclear Palsy
Knowledge Graph
Related Hypotheses (18)
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Phase-Separated Organelle Targeting
Score: 0.52
Noradrenergic-Tau Propagation Blockade
Score: 0.51
Stress Granule Phase Separation Modulators
Score: 0.49
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Lysosomal Enzyme Trafficking Correction
Score: 0.49
APOE Isoform Expression Across Glial Subtypes
Score: 0.48
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Lysosomal Membrane Repair Enhancement
Score: 0.45
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.44
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.38
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.37
Synaptic Vesicle Tau Capture Inhibition
Score: 0.34
Show 13 more
Related Analyses (7)
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Do tau strains or regional cellular environments primarily d
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
Show 2 more
Related Experiments (27)
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Levodopa Response Determinants in PSP — Biomarker-Guided Pre
clinical · proposed · Score: 0.40
PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40
Tau Pathology Initiation Zone Identification
clinical · proposed · Score: 0.40
Tau Spreading Network Mapping via Spatial Transcriptomics in
clinical · proposed · Score: 0.40
s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40
ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40
Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT
validation · proposed · Score: 0.40
C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40
Environmental Exposure Causal Attribution in ALS — Experimen
validation · proposed · Score: 0.40
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio
validation · proposed · Score: 0.40
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40
N-of-1 Clinical Trial Design for CBS/PSP
clinical · proposed · Score: 0.40
Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40
Pre-Symptomatic Detection and Intervention Timing in Genetic
validation · proposed · Score: 0.40
Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40
Sleep and Respiratory Network Interaction in ALS — Experimen
clinical · proposed · Score: 0.40
TDP-43 PET Ligand Development for FTD and ALS
clinical · proposed · Score: 0.40
Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40
Show 22 more
See Also (11)
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
DUSP10 Gene
gene · KG edge: associated_with
cdkn2a
gene · KG edge: associated_with
Genes
index · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: therapeutic_target
Apoptosis in Neurodegeneration
entity · KG edge: associated_with
Frontotemporal Dementia (FTD)
disease · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: expressed_in
Show 6 more
Knowledge Graph (12 edges)
PSP
downregulates
SV2A
PSP
associated_with
SP1
PSP
associated_with
APOE
PSP
associated_with
TAU
PSP
associated_with
KIF13A
PSP
associated_with
TRIM24
PSP
associated_with
STX6
PSP
associated_with
MAPT
PSP
activates
VPS29
PSP
activates
MAPT