🧫

Endothelial CD2AP knockdown effects on memory in male mice

experiment Created: 2026-04-06 12:34:46 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-009151de-c3f7-4b74-aea5-7
🧫 Experiment Protocol Animal Model
🧫 View Full Experiment Page →
Related Entities
CD2AP
Metadata
experiment_typeanimal_model
protocolgenetic downregulation of CD2AP in brain endothelial cells followed by behavioral memory testing
expected_outcomesreduced endothelial CD2AP impairs memory function in male mice
success_criteriasignificant memory deficits in CD2AP knockdown mice
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:34:46.497715
source_pmid39892386
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:34:46.520676'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (50)
derives_from📄Loss of endothelial CD2AP causes sex-dependent cerebrovascul100%
related🧫CD2AP downregulation in brain endothelial cells - memory fun100%
related🧫Cerebral blood flow regulation in CD2AP mutant mice100%
related🧫Reelin glycoprotein treatment rescue experiment100%
related🧫Cerebrovascular function analysis in CD2AP mutant mice100%
related🧫CD2AP loss association with cognitive decline in AD patients100%
mentions📖CD2AP Gene — CD2-Associated Protein70%
mentions📖CD2AP Synaptic Dysfunction Alzheimer's Disease Causal C70%
mentions📖CD2AP Protein70%
related📖CD2AP Gene — CD2-Associated Protein63%
related📖CD2AP Synaptic Dysfunction Alzheimer's Disease Causal C63%
related📖CD2AP Protein63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Brain Vascular Endothelial Cells60%
mentions📖Endothelial Cells60%
related🧫Endothelin-1 receptor A antagonist rescue in male CD2AP mice60%
related🧫Endothelin-1 receptor A antagonist rescue experiment60%
related🧫Reelin treatment rescue via ApoER2 in CD2AP mutant mice60%
related🧫Cerebral blood flow regulation in CD2AP mutant mice60%
related🧫Cerebrovascular function analysis in CD2AP mutant mice60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Brain Vascular Endothelial Cells54%
related📖Endothelial Cells54%

💬 Discussion