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Cerebrovascular function analysis in CD2AP mutant mice

experiment Created: 2026-04-06 12:34:31 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-e9c371ae-4aea-46c9-b21f-9
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Related Entities
CD2AP
Metadata
experiment_typeanimal_model
protocolmeasurement of blood flow regulation, neurovascular coupling, mural cell activity assessment
expected_outcomesaltered blood flow regulation and mural cell defects
success_criteriasignificant changes in cerebrovascular parameters compared to controls
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:34:31.016525
source_pmid39892386
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:34:31.055782'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (55)
derives_from📄Loss of endothelial CD2AP causes sex-dependent cerebrovascul100%
related🧫Endothelial CD2AP knockdown effects on memory in male mice100%
related🧫CD2AP expression and cognitive decline in AD patients100%
related🧫Endothelin-1 receptor A antagonist rescue in male CD2AP mice100%
related🧫Endothelin-1 receptor A antagonist rescue experiment100%
related🧫Reelin treatment rescue via ApoER2 in CD2AP mutant mice100%
related🧫CD2AP downregulation in brain endothelial cells - memory fun100%
related🧫Cerebral blood flow regulation in CD2AP mutant mice100%
related🧫Reelin glycoprotein treatment rescue experiment100%
related🧫CD2AP loss association with cognitive decline in AD patients100%
mentions📖CD2AP Gene — CD2-Associated Protein90%
mentions📖CD2AP Gene — CD2-Associated Protein70%
mentions📖CD2AP Synaptic Dysfunction Alzheimer's Disease Causal C70%
mentions📖CD2AP Protein70%
related📖CD2AP Gene — CD2-Associated Protein63%
related📖CD2AP Synaptic Dysfunction Alzheimer's Disease Causal C63%
related📖CD2AP Protein63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
related🧫Endothelial CD2AP knockdown effects on memory in male mice60%
related🧫CD2AP expression and cognitive decline in AD patients60%
related🧫Endothelin-1 receptor A antagonist rescue in male CD2AP mice60%
related🧫Endothelin-1 receptor A antagonist rescue experiment60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
mentions📖Alzheimer Hippocampal Circuit50%
mentions📖Amyotrophic Lateral Sclerosis (ALS)50%
mentions📖Endolysosomal Trafficking Defects in Neurodegeneration50%
mentions📖EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal Chain50%
mentions📖genetics44%

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