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Cognitive impact of TDP-43 pathology in AD patients

experiment Created: 2026-04-06 12:29:12 By: experiment_extractor Quality: 70% ✓ SciDEX ID: experiment-exp-1f297f00-3d27-4c16-bfb2-d
🧫 Experiment Protocol Clinical
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Related Entities
TARDBP
Metadata
experiment_typeclinical
protocolcognitive assessment and neuropathological examination correlation
expected_outcomesworse cognitive outcomes in AD patients with TDP-43 pathology
success_criteriastatistically significant difference in cognitive measures
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:29:12.335556
source_pmid34930382
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:29:12.357284'}
Linked Artifacts (102)
derives_from📄TDP-43 Pathology in Alzheimer's Disease.100%
related🧫TDP-43 pathology prevalence and distribution in AD cases100%
related🧪Cryptic Exon Silencing Restoration100%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding100%
related🧪Glycine-Rich Domain Competitive Inhibition100%
related🧪Cross-Seeding Prevention Strategy100%
mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%
mentions📖TARDBP — TAR DNA Binding Protein 4380%
mentions📖tardbp80%
mentions📖TARDBP/TDP-43 Protein80%
related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis72%
related📖TARDBP — TAR DNA Binding Protein 4372%
related📖tardbp72%
related📖TARDBP/TDP-43 Protein72%
mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%
mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%
mentions📖TDP-43 Aggregate Neurons70%
mentions📖cell-types-tdp-43-proteinopathy-neurons70%
mentions📖TDP-43 Proteinopathy Neurons70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 PET Ligand Development for FTD and ALS70%
mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%
mentions📖gaps-tdp-43-pet-ligand-ftd70%
mentions📖TDP-43 Splicing Modulation Therapy70%
mentions📖TDP-43 Proteinopathy Investment Landscape70%
mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%
mentions📖TDP-43 Proteinopathy in ALS70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%
mentions📖tdp-43-fus-rna-proteinopathy-comparison70%
mentions📖TDP-43 Proteinopathy70%
mentions📖TDP-43 Pathology Reversibility in ALS70%
mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%
mentions📖TDP-43 RNA Granule Pathway70%
mentions📖proteins-tar-db-protein70%
mentions📖TDP-43 Protein70%
mentions📖TDP-43 Protein70%
mentions📖proteins-tdp43_protein70%
related📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker63%
related📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia63%
related📖TDP-43 Aggregate Neurons63%
related📖cell-types-tdp-43-proteinopathy-neurons63%
related📖TDP-43 Proteinopathy Neurons63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 PET Ligand Development for FTD and ALS63%
related📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio63%
related📖gaps-tdp-43-pet-ligand-ftd63%
related📖TDP-43 Splicing Modulation Therapy63%
related📖TDP-43 Proteinopathy Investment Landscape63%
related📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis63%
related📖TDP-43 Proteinopathy in ALS63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 Co-pathology in Corticobasal Syndrome63%
related📖tdp-43-fus-rna-proteinopathy-comparison63%
related📖TDP-43 Proteinopathy63%
related📖TDP-43 Pathology Reversibility in ALS63%
related📖TDP-43 DNA Repair Mechanism in ALS and Dementia63%
related📖TDP-43 RNA Granule Pathway63%
related📖proteins-tar-db-protein63%
related📖TDP-43 Protein63%
related📖TDP-43 Protein63%
related📖proteins-tdp43_protein63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
related🧫TDP-43 mutant mouse model cGAS/STING pathway analysis60%
related🧫cGAMP biomarker analysis in ALS patient spinal cord samples60%
related🧫TDP-43 mitochondrial invasion and DNA release via mPTP60%
related🧫cGAS/STING pathway validation in TDP-43 mutant mice60%
related🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto60%
related🧫TDP-43 pathology prevalence and distribution in AD cases60%
related🧪Cryptic Exon Silencing Restoration60%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding60%
related🧪Glycine-Rich Domain Competitive Inhibition60%
related🧪Cross-Seeding Prevention Strategy60%
related📓Cryptic Exon Silencing Restoration -- Computational Analysis60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%