🧫

TDP-43 mutant mouse model cGAS/STING pathway analysis

experiment Created: 2026-04-06 12:28:36 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-62b2ebe2-1996-45ed-b23a-1
🧫 Experiment Protocol Animal Model
🧫 View Full Experiment Page →
Related Entities
TARDBP
Metadata
experiment_typeanimal_model
protocolAnalysis of TDP-43 mutant mice with pharmacologic inhibition or genetic deletion of cGAS/STING components, assessment of inflammatory markers and pathology
expected_outcomescGAS/STING inhibition reduces neuroinflammation in TDP-43 mutant mice
success_criteriaDecreased inflammatory cytokine levels and reduced pathology
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:28:36.707806
source_pmid33031745
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:28:36.749766'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (170)
derives_from📄TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activa100%
related🧫TDP-43 pathology prevalence and distribution in AD cases100%
related🧪Cryptic Exon Silencing Restoration100%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding100%
related🧪Glycine-Rich Domain Competitive Inhibition100%
related🧪Cross-Seeding Prevention Strategy100%
mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%
mentions📖TARDBP — TAR DNA Binding Protein 4380%
mentions📖tardbp80%
mentions📖TARDBP/TDP-43 Protein80%
related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis72%
related📖TARDBP — TAR DNA Binding Protein 4372%
related📖tardbp72%
related📖TARDBP/TDP-43 Protein72%
mentions📖ALS-FTD Overlap Neurons70%
mentions📖ALS Pipeline70%
mentions📖ALS Pipeline Companies70%
mentions📖ALS-FTD-Parkinsonism Comparison Matrix70%
mentions📖ALS-FTD Spectrum70%
mentions📖ALS Progression Rate Heterogeneity70%
mentions📖ALS Progression Rate Heterogeneity — mechanism and biomarker70%
mentions📖ALS Regional Onset and Spread: Network-Level Staging Model70%
mentions📖gaps-als70%
mentions📖gaps-als-immune-signature-stratification70%
mentions📖gaps-als-motor-neuron-vulnerability70%
mentions📖gaps-als-progression-rate-heterogeneity70%
mentions📖gaps-als-regional-onset-spread70%
mentions📖ALS Trial Failures Knowledge Gap70%
mentions📖ALS Association70%
mentions📖ALS Clinical Trials Consortium (NEALS)70%
mentions📖ALS vs FTD: Comparative Investment Analysis70%
mentions📖ALS Biomarker-to-Mechanism Mapping70%
mentions📖ALS Biomarkers and Disease Monitoring70%
mentions📖ALS Combination Therapy Matrix70%
mentions📖ALS Cure Roadmap70%
mentions📖ALS Failed Approaches Analysis70%
mentions📖ALS-FTD Overlap: Mechanistic Pathways70%
mentions📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms70%
mentions📖ALS Knowledge Gaps Ranked List70%
mentions📖ALS Disease Spectrum vs Molecular Subtypes70%
mentions📖ALS Mechanistic Pathway70%
mentions📖ALS Progression Trajectories70%
mentions📖ALS RNA Metabolism and Proteostasis Failure70%
mentions📖ALS Therapeutic Scorecard70%
mentions📖ALS Trial Failure Analysis70%
mentions📖ALS Communication Brain-Computer Interfaces70%
mentions📖ALS Cure Roadmap70%
mentions📖ALS Therapeutic Landscape — Programs by Phase and Modality70%
mentions📖ALS Therapeutics70%
mentions📖ALS Treatment Overview70%
mentions📖ALS Treatment Strategies70%
mentions📖STING Gene70%
mentions📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease70%
mentions📖proteins-sting-protein70%
mentions📖STING Protein70%
mentions📖STING Inhibitor Therapy in Neurodegeneration70%
mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%
mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%
mentions📖TDP-43 Aggregate Neurons70%
mentions📖cell-types-tdp-43-proteinopathy-neurons70%
mentions📖TDP-43 Proteinopathy Neurons70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 PET Ligand Development for FTD and ALS70%
mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%
mentions📖gaps-tdp-43-pet-ligand-ftd70%
mentions📖TDP-43 Splicing Modulation Therapy70%
mentions📖TDP-43 Proteinopathy Investment Landscape70%
mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%
mentions📖TDP-43 Proteinopathy in ALS70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%
mentions📖tdp-43-fus-rna-proteinopathy-comparison70%
mentions📖TDP-43 Proteinopathy70%
mentions📖TDP-43 Pathology Reversibility in ALS70%
mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%
mentions📖TDP-43 RNA Granule Pathway70%
mentions📖proteins-tar-db-protein70%
mentions📖TDP-43 Protein70%
mentions📖TDP-43 Protein70%
mentions📖proteins-tdp43_protein70%
related📖ALS-FTD Overlap Neurons63%
related📖ALS Pipeline63%
related📖ALS Pipeline Companies63%
related📖ALS-FTD-Parkinsonism Comparison Matrix63%
related📖ALS-FTD Spectrum63%
related📖ALS Progression Rate Heterogeneity63%
related📖ALS Progression Rate Heterogeneity — mechanism and biomarker63%
related📖ALS Regional Onset and Spread: Network-Level Staging Model63%
related📖gaps-als63%
related📖gaps-als-immune-signature-stratification63%
related📖gaps-als-motor-neuron-vulnerability63%
related📖gaps-als-progression-rate-heterogeneity63%
related📖gaps-als-regional-onset-spread63%
related📖ALS Trial Failures Knowledge Gap63%
related📖ALS Association63%
related📖ALS Clinical Trials Consortium (NEALS)63%
related📖ALS vs FTD: Comparative Investment Analysis63%
related📖ALS Biomarker-to-Mechanism Mapping63%
related📖ALS Biomarkers and Disease Monitoring63%
related📖ALS Combination Therapy Matrix63%
related📖ALS Cure Roadmap63%
related📖ALS Failed Approaches Analysis63%
related📖ALS-FTD Overlap: Mechanistic Pathways63%
related📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms63%
related📖ALS Knowledge Gaps Ranked List63%
related📖ALS Disease Spectrum vs Molecular Subtypes63%
related📖ALS Mechanistic Pathway63%
related📖ALS Progression Trajectories63%
related📖ALS RNA Metabolism and Proteostasis Failure63%
related📖ALS Therapeutic Scorecard63%
related📖ALS Trial Failure Analysis63%
related📖ALS Communication Brain-Computer Interfaces63%
related📖ALS Cure Roadmap63%
related📖ALS Therapeutic Landscape — Programs by Phase and Modality63%
related📖ALS Therapeutics63%
related📖ALS Treatment Overview63%
related📖ALS Treatment Strategies63%
related📖STING Gene63%
related📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease63%
related📖proteins-sting-protein63%
related📖STING Protein63%
related📖STING Inhibitor Therapy in Neurodegeneration63%
related📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker63%
related📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia63%
related📖TDP-43 Aggregate Neurons63%
related📖cell-types-tdp-43-proteinopathy-neurons63%
related📖TDP-43 Proteinopathy Neurons63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 PET Ligand Development for FTD and ALS63%
related📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio63%
related📖gaps-tdp-43-pet-ligand-ftd63%
related📖TDP-43 Splicing Modulation Therapy63%
related📖TDP-43 Proteinopathy Investment Landscape63%
related📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis63%
related📖TDP-43 Proteinopathy in ALS63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 Co-pathology in Corticobasal Syndrome63%
related📖tdp-43-fus-rna-proteinopathy-comparison63%
related📖TDP-43 Proteinopathy63%
related📖TDP-43 Pathology Reversibility in ALS63%
related📖TDP-43 DNA Repair Mechanism in ALS and Dementia63%
related📖TDP-43 RNA Granule Pathway63%
related📖proteins-tar-db-protein63%
related📖TDP-43 Protein63%
related📖TDP-43 Protein63%
related📖proteins-tdp43_protein63%
mentions📖Amyotrophic Lateral Sclerosis (ALS)60%
mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
mentions📖Bulbar Amyotrophic Lateral Sclerosis60%
mentions📖FUS Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖SOD1 Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖Spinal Amyotrophic Lateral Sclerosis60%
related🧫Cognitive impact of TDP-43 pathology in AD patients60%
related🧫cGAMP biomarker analysis in ALS patient spinal cord samples60%
related🧫TDP-43 mitochondrial invasion and DNA release via mPTP60%
related🧫cGAS/STING pathway validation in TDP-43 mutant mice60%
related🧫TDP-43 mitochondrial invasion and mtDNA release in iPSC moto60%
related🧫TDP-43 pathology prevalence and distribution in AD cases60%
related🧪Cryptic Exon Silencing Restoration60%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding60%
related🧪Glycine-Rich Domain Competitive Inhibition60%
related🧪Cross-Seeding Prevention Strategy60%
related📓Cryptic Exon Silencing Restoration -- Computational Analysis60%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
related📖Amyotrophic Lateral Sclerosis (ALS)54%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants54%
related📖Bulbar Amyotrophic Lateral Sclerosis54%
related📖FUS Mutations in Amyotrophic Lateral Sclerosis54%
related📖SOD1 Mutations in Amyotrophic Lateral Sclerosis54%
related📖Spinal Amyotrophic Lateral Sclerosis54%

💬 Discussion