🧫

TDP-43 mitochondrial invasion and DNA release via mPTP

experiment Created: 2026-04-06 12:28:36 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-8575c9eb-9a3a-4d9a-9a26-e
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TARDBP
Metadata
experiment_typecell_biology
protocolAssessment of TDP-43 localization to mitochondria, measurement of mitochondrial permeability transition pore opening, and detection of cytoplasmic mtDNA release
expected_outcomesTDP-43 invasion of mitochondria triggers mPTP opening and subsequent mtDNA release
success_criteriaDetection of mtDNA in cytoplasm following TDP-43 mitochondrial invasion
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:28:36.707796
source_pmid33031745
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:28:36.710159'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (140)
derives_from📄TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activa100%
related🧫TDP-43 pathology prevalence and distribution in AD cases100%
related🧪Cryptic Exon Silencing Restoration100%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding100%
related🧪Glycine-Rich Domain Competitive Inhibition100%
related🧪Cross-Seeding Prevention Strategy100%
mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%
mentions📖TARDBP — TAR DNA Binding Protein 4380%
mentions📖tardbp80%
mentions📖TARDBP/TDP-43 Protein80%
related📖TARDBP Mutations in Amyotrophic Lateral Sclerosis72%
related📖TARDBP — TAR DNA Binding Protein 4372%
related📖tardbp72%
related📖TARDBP/TDP-43 Protein72%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Methylation70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖dna-damage-repair70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA Damage Response in Neurons70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖DNA Ligase III Protein70%
mentions📖DNA Ligase IV Protein70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%
mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%
mentions📖TDP-43 Aggregate Neurons70%
mentions📖cell-types-tdp-43-proteinopathy-neurons70%
mentions📖TDP-43 Proteinopathy Neurons70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 PET Ligand Development for FTD and ALS70%
mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%
mentions📖gaps-tdp-43-pet-ligand-ftd70%
mentions📖TDP-43 Splicing Modulation Therapy70%
mentions📖TDP-43 Proteinopathy Investment Landscape70%
mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%
mentions📖TDP-43 Proteinopathy in ALS70%
mentions📖TDP-43 Pathology in Corticobasal Syndrome70%
mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%
mentions📖tdp-43-fus-rna-proteinopathy-comparison70%
mentions📖TDP-43 Proteinopathy70%
mentions📖TDP-43 Pathology Reversibility in ALS70%
mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%
mentions📖TDP-43 RNA Granule Pathway70%
mentions📖proteins-tar-db-protein70%
mentions📖TDP-43 Protein70%
mentions📖TDP-43 Protein70%
mentions📖proteins-tdp43_protein70%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Methylation63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Repair Investment Landscape63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖dna-damage-repair63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖DNA Damage Response Impairment Pathway63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Ligase III Protein63%
related📖DNA Ligase IV Protein63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker63%
related📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia63%
related📖TDP-43 Aggregate Neurons63%
related📖cell-types-tdp-43-proteinopathy-neurons63%
related📖TDP-43 Proteinopathy Neurons63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 PET Ligand Development for FTD and ALS63%
related📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio63%
related📖gaps-tdp-43-pet-ligand-ftd63%
related📖TDP-43 Splicing Modulation Therapy63%
related📖TDP-43 Proteinopathy Investment Landscape63%
related📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis63%
related📖TDP-43 Proteinopathy in ALS63%
related📖TDP-43 Pathology in Corticobasal Syndrome63%
related📖TDP-43 Co-pathology in Corticobasal Syndrome63%
related📖tdp-43-fus-rna-proteinopathy-comparison63%
related📖TDP-43 Proteinopathy63%
related📖TDP-43 Pathology Reversibility in ALS63%
related📖TDP-43 DNA Repair Mechanism in ALS and Dementia63%
related📖TDP-43 RNA Granule Pathway63%
related📖proteins-tar-db-protein63%
related📖TDP-43 Protein63%
related📖TDP-43 Protein63%
related📖proteins-tdp43_protein63%
mentions📖Amyotrophic Lateral Sclerosis (ALS)60%
mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
mentions📖Bulbar Amyotrophic Lateral Sclerosis60%
mentions📖FUS Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖SOD1 Mutations in Amyotrophic Lateral Sclerosis60%
mentions📖Spinal Amyotrophic Lateral Sclerosis60%
mentions📖Mitochondria60%
related🧫Cognitive impact of TDP-43 pathology in AD patients60%
related🧫TDP-43 mutant mouse model cGAS/STING pathway analysis60%
related🧫cGAMP biomarker analysis in ALS patient spinal cord samples60%
related🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding60%
related📓Cryptic Exon Silencing Restoration -- Computational Analysis60%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%
related📖Amyotrophic Lateral Sclerosis (ALS)54%
related📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants54%
related📖Bulbar Amyotrophic Lateral Sclerosis54%
related📖FUS Mutations in Amyotrophic Lateral Sclerosis54%
related📖SOD1 Mutations in Amyotrophic Lateral Sclerosis54%
related📖Spinal Amyotrophic Lateral Sclerosis54%
related📖Mitochondria54%