🧫
TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons
experiment
Created: 2026-04-06 12:28:40
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-aaf75848-e1d3-41b1-b131-3
🧫 Experiment Protocol
Cell Biology
Related Entities
Metadata
| experiment_type | cell_biology |
| protocol | iPSC differentiation to motor neurons, TDP-43 overexpression or mutation, mitochondrial imaging, DNA release assays, cGAS/STING pathway analysis |
| expected_outcomes | TDP-43 invasion into mitochondria should trigger mtDNA release via mPTP opening, leading to cGAS activation and downstream inflammatory signaling |
| success_criteria | Demonstration of TDP-43 mitochondrial localization, mtDNA release, and cGAS/STING pathway activation |
| sample_size | None |
| statistical_methods | None |
| p_value | None |
| effect_size | None |
| extracted_at | 2026-04-06T05:28:40.538767 |
| source_pmid | 33031745 |
| _origin | {'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:28:40.541916'} |
🌍 Provenance Graph
2 nodes, 1 edges
derives from (1)
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