🧫

Cell type-specific P2rx7 deletion in microglia vs astrocytes

experiment Created: 2026-04-12 18:03:52 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-2aa445e2-aed9-4ecd-ad42-d
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Related Entities
P2rx7
Metadata
experiment_typeanimal_model
protocolCell type-specific P2rx7 deletion using Cre-lox system, followed by tau pathology assessment in specific brain regions
expected_outcomesMicroglial P2rx7 deletion would suppress tau propagation more than astrocytic deletion
success_criteriaSignificant reduction in tau propagation with microglial but not astrocytic P2rx7 deletion
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-12T11:03:51.877222
source_pmid40678243
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-12T18:03:52.037354'}
Linked Artifacts (35)
related🧫P2rx7 congenic mouse model insulin tolerance testing100%
related🧫BDEV injection and recipient microglial transcriptome analys100%
related🧫P2rx7 congenic mouse model glucose tolerance testing100%
related🧫Single-cell RNA sequencing of mouse brains100%
related🧫P2RX7 variant rs1718119 association with glucose homeostasis100%
mentions📖p2rx780%
mentions📖P2RX7 Protein80%
related📖p2rx772%
related📖P2RX7 Protein72%
mentions📖Astrocytes60%
mentions📖Astrocytes60%
mentions📖brain-regions60%
mentions📖cell-types60%
mentions📖Entorhinal Cortex60%
mentions📖Hippocampus60%
mentions📖mechanisms60%
mentions📖Microglia60%
mentions📖Microglia60%
mentions📖researchers60%
mentions📖Tau Pathology60%
mentions📖Tauopathy60%
related📖Alzheimer's Disease60%
related📖Alzheimer's Disease54%
related📖Astrocytes54%
related📖Astrocytes54%
related📖brain-regions54%
related📖cell-types54%
related📖Entorhinal Cortex54%
related📖Hippocampus54%
related📖mechanisms54%
related📖Microglia54%
related📖Microglia54%
related📖researchers54%
related📖Tau Pathology54%
related📖Tauopathy54%