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Single-cell RNA sequencing of microglial states in AD hippocampus

experiment Created: 2026-04-06 12:26:59 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-9d234335-0d58-4342-98ee-b
🧫 Experiment Protocol Gene Expression
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Related Entities
SPP1
Metadata
experiment_typegene_expression
protocolSingle-cell RNA sequencing of hippocampal tissue with bioinformatics analysis of microglial cell states
expected_outcomesIdentification of SPP1-induced phagocytic microglial states
success_criteriaDetection of distinct microglial transcriptional signatures associated with SPP1 signaling
sample_sizeNone
statistical_methodsSingle-cell RNA sequencing analysis methods
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:26:59.117769
source_pmid36747024
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:26:59.174033'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (98)
derives_from📄Perivascular cells induce microglial phagocytic states and s100%
related🧫SPP1-mediated microglial synaptic engulfment assay100%
related🧫SPP1 upregulation in perivascular cells in AD mouse models100%
related🧫Spp1 knockout prevents synaptic loss in AD mouse models100%
related🧫Cell-cell interaction analysis of perivascular-microglial cr100%
mentions📖SPP1 Gene80%
related📖SPP1 Gene72%
mentions📖RNA Binding Fox-1 Homolog 1 (RBFOX1)70%
mentions📖RNA Binding Fox-1 Homolog 2 (RBFOX2)70%
mentions📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)70%
mentions📖RNA Therapeutics: Investment Landscape Analysis70%
mentions📖RNA Therapeutics for Neurodegeneration Investment Landscape70%
mentions📖RNA Metabolism Dysfunction in Corticobasal Syndrome70%
mentions📖RNA Metabolism Dysregulation in Alzheimer's Disease70%
mentions📖RNA G-quadruplexes in Neurodegeneration70%
mentions📖RNA Granule Dysfunction in Neurodegeneration70%
mentions📖RNA Metabolism in Neurodegeneration70%
mentions📖RNA Metabolism Dysregulation in 4R-Tauopathies70%
mentions📖RNA Metabolism in Alzheimer's Disease70%
mentions📖RNA Metabolism Dysregulation Pathway70%
mentions📖RNA Processing in Neurodegeneration70%
mentions📖RNA Splicing in Neurodegeneration70%
mentions📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 70%
mentions📖RNA Splicing Defects in Neurodegeneration70%
mentions📖RNA Stability and Decay70%
mentions📖RNA-Targeted Therapies in Neurodegeneration70%
mentions📖RNA-Targeted Therapeutics Investment Synthesis70%
mentions📖RNA Toxicity Pathway70%
mentions📖RNA Editing Therapeutics70%
mentions📖RNA-Based Therapeutics for Alzheimer's Disease70%
mentions📖RNA-Targeting Therapies for Neurodegenerative Diseases70%
mentions📖RNA Targeting Therapy for Neurodegeneration70%
mentions📖RNA-Based Therapeutics for Neurodegenerative Diseases70%
mentions📖RNA Interference (RNAi) Therapies for Neurodegeneration70%
related📖RNA Binding Fox-1 Homolog 1 (RBFOX1)63%
related📖RNA Binding Fox-1 Homolog 2 (RBFOX2)63%
related📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)63%
related📖RNA Therapeutics: Investment Landscape Analysis63%
related📖RNA Therapeutics for Neurodegeneration Investment Landscape63%
related📖RNA Metabolism Dysfunction in Corticobasal Syndrome63%
related📖RNA Metabolism Dysregulation in Alzheimer's Disease63%
related📖RNA G-quadruplexes in Neurodegeneration63%
related📖RNA Granule Dysfunction in Neurodegeneration63%
related📖RNA Metabolism in Neurodegeneration63%
related📖RNA Metabolism Dysregulation in 4R-Tauopathies63%
related📖RNA Metabolism in Alzheimer's Disease63%
related📖RNA Metabolism Dysregulation Pathway63%
related📖RNA Processing in Neurodegeneration63%
related📖RNA Splicing in Neurodegeneration63%
related📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 63%
related📖RNA Splicing Defects in Neurodegeneration63%
related📖RNA Stability and Decay63%
related📖RNA-Targeted Therapies in Neurodegeneration63%
related📖RNA-Targeted Therapeutics Investment Synthesis63%
related📖RNA Toxicity Pathway63%
related📖RNA Editing Therapeutics63%
related📖RNA-Based Therapeutics for Alzheimer's Disease63%
related📖RNA-Targeting Therapies for Neurodegenerative Diseases63%
related📖RNA Targeting Therapy for Neurodegeneration63%
related📖RNA-Based Therapeutics for Neurodegenerative Diseases63%
related📖RNA Interference (RNAi) Therapies for Neurodegeneration63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Hippocampus60%
mentions📖mechanisms60%
mentions📖Microglia60%
mentions📖Microglia60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Hippocampus54%
related📖mechanisms54%
related📖Microglia54%
related📖Microglia54%

💬 Discussion