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SPP1-mediated microglial synaptic engulfment assay

experiment Created: 2026-04-06 12:26:59 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-01066b75-ea4d-4a55-8465-7
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SPP1
Metadata
experiment_typecell_biology
protocolPhagocytosis assays measuring synaptic engulfment and expression of C1qa, Grn, Ctsb markers
expected_outcomesSPP1-dependent increase in microglial synaptic engulfment and phagocytic markers
success_criteriaSignificant upregulation of phagocytic markers and increased synaptic engulfment with SPP1
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-06T05:26:59.117766
source_pmid36747024
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-06T12:26:59.139797'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (46)
derives_from📄Perivascular cells induce microglial phagocytic states and s100%
related🧫SPP1 upregulation in perivascular cells in AD mouse models100%
related🧫Spp1 knockout prevents synaptic loss in AD mouse models100%
related🧫Cell-cell interaction analysis of perivascular-microglial cr100%
related🧫Single-cell RNA sequencing of microglial states in AD hippoc100%
mentions📖SPP1 Gene70%
related📖SPP1 Gene63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Microglia60%
mentions📖Microglia60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Microglia54%
related📖Microglia54%
mentions📖Perivascular Macrophages50%
mentions📖Lateral Superior Olive (LSO) Neurons44%
mentions📖Medial Nucleus of the Trapezoid Body (MNTB) Neurons44%
mentions📖Microglia in Chronic Neuroinflammation44%
mentions📖Trapezoid Body Complex44%
mentions📖Microglial Polarization44%