🧫
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Concomitant NPH
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
95%
✓ SciDEX
ID: experiment-exp-wiki-diagnostics-nph-csf-
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'paper', 'pmid': '39180980', 'extraction_date': '2026-04-16T01:00:16.896718Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['AQP1/AQP4/HCRTR1'], 'diseases': ["Alzheimer's Disease"], 'pathways': ['HDAC4-Mef2A-eNOS signaling pathway', 'CaMKII-AMPK signaling']} |
| model_system | aortic endothelial cells |
| summary | # CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Concomitant NPH ## Background and Rationale Normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) present a complex dia |
| replication_status | single_study |
| methodology_notes | ## PROTOCOL: CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Concomitant NPH **Phase 1: Patient Recruitment and Stratification (Months 1-6)** Recruit 240 participants across three |
| primary_outcome | cellular senescence phenotype and angiogenic capacity |
| extraction_metadata | {'extraction_confidence': 0.9, 'needs_review': False, 'extraction_notes': 'Backfilled from wiki source via PMID 39180980', 'backfill_at': '2026-04-16T01:00:16.896729'} |
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