Datasets

This index provides a comprehensive catalog of datasets relevant to neurodegenerative disease research, covering genomics, transcriptomics, proteomics, neuroimaging, and clinical data from major international consortia and research institutions. These datasets are essential resources for understanding disease mechanisms, identifying therapeutic targets, and developing biomarkers for Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, frontotemporal dementia, and other neurodegenerative conditions.

Neurodegenerative diseases affect millions of people worldwide, and understanding their underlying biology requires large-scale, high-quality datasets. The research community has generated numerous public datasets spanning multiple modalities including genomic datasets, transcriptomic datasets, proteomic datasets, neuroimaging datasets, clinical datasets, and neuropathology datasets[@beach2021].

The past decade has seen an unprecedented expansion in the availability of large-scale biomedical datasets, driven by decreasing sequencing costs, increased neuroimaging capacity, and coordinated international efforts to share data. This democratization of data has transformed neurodegenerative disease research, enabling unprecedented insights into disease mechanisms and accelerating therapeutic development[@weiner2012].
_Total: 26 pages_

Major Dataset Pages

This index provides a comprehensive catalog of datasets relevant to neurodegenerative disease research, covering genomics, transcriptomics, proteomics, neuroimaging, and clinical data from major international consortia and research institutions. These datasets are essential resources for understanding disease mechanisms, identifying therapeutic targets, and developing biomarkers for Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease, frontotemporal dementia, and other neurodegenerative conditions.

Neurodegenerative diseases affect millions of people worldwide, and understanding their underlying biology requires large-scale, high-quality datasets. The research community has generated numerous public datasets spanning multiple modalities including genomic datasets, transcriptomic datasets, proteomic datasets, neuroimaging datasets, clinical datasets, and neuropathology datasets[@beach2021].

The past decade has seen an unprecedented expansion in the availability of large-scale biomedical datasets, driven by decreasing sequencing costs, increased neuroimaging capacity, and coordinated international efforts to share data. This democratization of data has transformed neurodegenerative disease research, enabling unprecedented insights into disease mechanisms and accelerating therapeutic development[@weiner2012].
_Total: 26 pages_

Major Dataset Pages

• [Australian Imaging Biomarker Lifestyle Flagship Study of Ageing (AIBL)](/datasets/aibl)
• [Allen Brain Atlas Datasets](/datasets/allen-brain-atlas)
• [Allen Brain Cell (ABC) Atlas](/datasets/allen-brain-cell-atlas)
• [Allen Human Brain Atlas](/datasets/allen-human-brain-atlas)
• [Allen Mouse Brain Atlas](/datasets/allen-mouse-brain-atlas)
• [Allen OpenScope Program](/datasets/allen-openscope)
• [AMP-PD: Accelerating Medicines Partnership: Parkinson's Disease and Related Disorders](/datasets/amp-pd)
• [BrainSpan Atlas](/datasets/brainspan-atlas)
• [Allen Cell Types Atlas](/datasets/cell-types-atlas)
• [Datasets Dashboard](/datasets/dashboard)
• [Dominantly Inherited Alzheimer Network (DIAN) Dataset](/datasets/dian)
• [FTD Dataset Rankings](/datasets/ftd-rankings)
• [GENIE: Genetic and Environmental Risk for Alzheimer's Disease](/datasets/genie)
• [NIH Blueprint for Enhancing the Development of Neuroimaging Tools](/datasets/nih-blueprint-neuroimaging)
• [Open Access Series of Imaging Studies (OASIS)](/datasets/oasis)
• [Dataset Overview](/datasets/overview)
• [Parkinson's Progression Markers Initiative (PPMI)](/datasets/ppmi)
• [Dataset Rankings](/datasets/rankings)
• [UK Biobank](/datasets/uk-biobank)

Key Dataset Projects

| Dataset | Focus Area | Institution | Participants | Data Types |
|---------|------------|--------------|--------------|------------|
| ADNI | Alzheimer's disease neuroimaging | University of California | 1,000+ | MRI, PET, CSF, genetic |
| PPMI | Parkinson's disease biomarkers | Michael J. Fox Foundation | 1,000+ | Clinical, imaging, biospecimens |
| AMP-AD | Alzheimer's disease proteomics | Multiple | 2,000+ | RNA-seq, proteomics |
| Allen Brain Atlas | Brain transcriptomics | Allen Institute | N/A | Transcriptomic |
| UK Biobank | Population genetics | Wellcome Trust | 500,000 | Genetic, imaging, clinical |
| PDBP | Parkinson's disease progression | National Institutes of Health | 2,000+ | Clinical, imaging |
| Project MinE | ALS genetics | Multiple | 15,000 planned | Whole genome sequencing |
| DIAN | Familial Alzheimer's | Washington University | 500+ | Longitudinal biomarker |

How to Access These Datasets

Most datasets require registration and acceptance of data use agreements. Key access portals include:

• NIAGADS (National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site): Primary repository for ADNI and related Alzheimer's disease datasets
• LONI IDA (Laboratory of Neuro Imaging Image and Data Archive): Neuroimaging data from ADNI and other studies
• Synapse (AMP-AD and other NIH-funded data): Multi-omics data from the Accelerating Medicines Partnership
• dbGaP (Database of Genotypes and Phenotypes): Genomic data from NIH-funded studies
• GEO (Gene Expression Omnibus): Transcriptomic datasets from neurodegenerative disease studies
• AWS Open Data: Cloud-based access to large datasets including UK Biobank

Related Sections

• [Technologies](/technologies) — Technologies used in data acquisition](/technologies)
• [Institutions](/institutions) — Institutions leading dataset collection](/institutions)
• [Researchers](/researchers) — Researchers working with these datasets](/datasets)
• [Alzheimer's Disease](/diseases/alzheimers-disease) — Diseases studied using these datasets](/datasets)
• [Parkinson's Disease](/diseases/parkinsons-disease) — Related disease datasets](/datasets)
• [ALS](/diseases/amyotrophic-lateral-sclerosis) — Motor neuron disease datasets

See Also

• [Genomics](/technologies/single-cell-genomics) — Genetic analysis methods
• [Proteomics](/technologies/proteomics) — Protein analysis methods
• [Neuroimaging](/diagnostics/neuroimaging) — Brain imaging technologies

Related Hypotheses

From the [SciDEX Exchange](/exchange) — scored by multi-agent debate

• [Prefrontal sensory gating circuit restoration via PV interneuron enhancement](/hypothesis/h-62f9fc90) — <span style="color:#81c784;font-weight:600">0.72</span> · Target: PVALB
• [Smartphone-Detected Motor Variability Correction](/hypothesis/h-072b2f5d) — <span style="color:#81c784;font-weight:600">0.63</span> · Target: DRD2/SNCA
• [Targeted APOE4-to-APOE3 Base Editing Therapy](/hypothesis/h-a20e0cbb) — <span style="color:#ffd54f;font-weight:600">0.59</span> · Target: APOE
• [Enteric Nervous System Prion-Like Propagation Blockade](/hypothesis/h-2e7eb2ea) — <span style="color:#ffd54f;font-weight:600">0.55</span> · Target: TLR4, SNCA
• [KDM6A-Mediated H3K27me3 Rejuvenation](/hypothesis/h-881362dc) — <span style="color:#ffd54f;font-weight:600">0.49</span> · Target: KDM6A
• [Vocal Cord Neuroplasticity Stimulation](/hypothesis/h-e0183502) — <span style="color:#ffd54f;font-weight:600">0.48</span> · Target: CHR2/BDNF
• [Age-Dependent Complement C4b Upregulation Drives Synaptic Vulnerability in Hippocampal CA1 Neurons](/hypothesis/h-2f43b42f) — <span style="color:#81c784;font-weight:600">0.70</span> · Target: C4B
• [The Glial Ketone Metabolic Shunt Hypothesis](/hypothesis/h-4b517512) — <span style="color:#ffd54f;font-weight:600">0.51</span> · Target: HMGCS2

Related Analyses:

• [Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability](/analysis/SDA-2026-04-02-gap-aging-mouse-brain-20260402) &#x1f504;
• [Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability](/analysis/SDA-2026-04-02-gap-aging-mouse-brain-v2-20260402) &#x1f504;
• [Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability](/analysis/SDA-2026-04-02-gap-aging-mouse-brain-v3-20260402) &#x1f504;
• [Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability](/analysis/SDA-2026-04-02-gap-aging-mouse-brain-v4-20260402) &#x1f504;
• [Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability](/analysis/SDA-2026-04-02-gap-aging-mouse-brain-v5-20260402) &#x1f504;