Circadian Glymphatic Rescue Therapy (Melatonin-focused)

**Molecular Mechanism and Rationale** The circadian glymphatic rescue therapy centers on the intricate molecular interplay between melatonin receptor signaling, circadian clock machinery, and glymphatic system components. Melatonin exerts its effects primarily through two G-protein coupled receptors: MTNR1A (MT1) and MTNR1B (MT2), both highly expressed in suprachiasmatic nucleus (SCN) neurons and astrocytes throughout the brain parenchyma. Upon binding to MT1 receptors, melatonin activates Gi/G...