Osmotic Gradient Restoration via Selective AQP1 Enhancement in Choroid Plexus

**Molecular Mechanism and Rationale** Aquaporin-1 (AQP1) represents a critical water channel protein predominantly expressed in the apical membrane of choroid plexus epithelial cells, where it facilitates the bulk water transport necessary for cerebrospinal fluid (CSF) production. The molecular mechanism underlying AQP1-mediated CSF formation involves the coordinated function of multiple transport proteins and ion channels within choroid plexus epithelial cells. AQP1 works in concert with the N...