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SAMHD1 — SAM and HD Domain Containing Metal Dependent Hydrolase 1

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slug	genes-samhd1
entity_type	gene
kg_node_id	SAMHD1

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mentions🧪Purinergic Signaling Polarization Control70%

mentions🧪Lipid Droplet Dynamics as Phenotype Switches70%

mentions🧪Mechanosensitive Ion Channel Reprogramming70%

related🧫Epigenetic Dysregulation in Huntington's Disease — Ther70%

related🧫Microglial Contributions to Huntington's Disease Pathog70%

related🧫Macroautophagy Dysfunction in PD - Experiment Design70%

related🧫Epigenetic Dysregulation in Huntington's Disease — Ther70%

related🧫Microglial Contributions to Huntington's Disease Pathog70%

related🧫Macroautophagy Dysfunction in PD - Experiment Design70%

related🧪Purinergic Signaling Polarization Control63%

related🧪Lipid Droplet Dynamics as Phenotype Switches63%

related🧪Mechanosensitive Ion Channel Reprogramming63%

see_also📖diseases-amyotrophic-lateral-sclerosis60%

see_also📖OPTN — Optineurin60%

see_also📖TREX1 — Three Prime Repair Exonuclease 160%

see_also📖Alzheimer Indonesia60%

see_also📖Neurodegeneration60%

see_also📖Genes60%

see_also📖Packard Center for ALS Research60%

see_also📖Complement System Dysregulation in Neurodegeneration - Resea60%

see_also📖CTC1 Gene60%

see_also📖LMNA Gene60%

see_also📖MDM2 Gene60%

see_also📖POLD160%

see_also📖POLD1 Protein60%

see_also📖ATM Gene60%

see_also📖MRE11 Gene60%

see_also📖MUTYH Gene60%

see_also📖NBS1 (NBN)60%

see_also📖NEIL1 — Nei Endonuclease VIII-Like 160%

see_also📖POT1 Gene60%

see_also📖WRN — Werner Syndrome RecQ Like Helicase60%

see_also📖IKBKG Gene60%

mentions🧪VCP-Mediated Autophagy Enhancement50%

mentions🧪Optogenetic Control of Mitochondrial Transfer Networks50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu50%

mentions🧪Low Complexity Domain Cross-Linking Inhibition50%

mentions🧪Glycine-Rich Domain Competitive Inhibition50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪RAB27A-dependent extracellular vesicle engineering for mitoc50%

mentions🧪Near-infrared light therapy stimulates COX4-dependent mitoch50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

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related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬Investigate prion-like spreading of tau pathology through co50%

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see_also📖GBA Brain Molecular Imaging and Blood Biomarkers for Precisi45%

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see_also📖Phase 3 Study to Compare the Efficacy and Safety of Masitini45%

see_also📖Safety and Clinical Outcomes Study: Amniotic and Umbilical C45%

see_also📖A Phase IIB, Randomized, Double-Blind, Placebo-Controlled, M45%

see_also📖A Phase III, Randomized, Double-Blind, Placebo-Controlled, M45%

see_also📖A Multicenter, Phase III, Randomized, Double Blind, Placebo-45%

see_also📖A Phase 2b, Multicenter, Randomized, Double-Blind, Placebo-C45%

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see_also📖HIV-Associated Neurocognitive Disorders (HAND)45%

see_also📖Hemiballismus and Hemichorea in Corticobasal Syndrome45%

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see_also📖Investment Landscape: Parkinson's Disease45%

see_also📖Japan Neurodegeneration Epidemiology45%

see_also📖Japanese and German Case Series in Corticobasal Degeneration45%

see_also📖Jervell and Lange-Nielsen Syndrome45%

see_also📖LRRK2 Gene Variants and Mutations45%

see_also📖Manganese-Related Neurodegeneration (Manganism)45%

see_also📖MELAS Syndrome (Mitochondrial Encephalomyopathy, Lactic Acid45%

see_also📖Mirror Therapy and Sensory Re-education in Corticobasal Synd45%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison45%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr45%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 45%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)45%

see_also📖Potential Impact Measures — Neurodegeneration45%

see_also📖Nutritional Support and Dietary Interventions in Corticobasa45%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)45%

see_also📖Physical and Occupational Therapy in Corticobasal Syndrome45%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)45%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)45%

see_also📖Postural Dysfunction and Abnormalities in Corticobasal Syndr45%

see_also📖Pseudobulbar Affect and Emotional Lability in Corticobasal S45%

see_also📖Healthcare Economics and Cost of Illness in Progressive Supr45%

see_also📖PSP and Idiopathic Normal Pressure Hydrocephalus: Clinical O45%

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see_also📖Speech and Voice Disorders in PSP45%

see_also📖Sandhoff Disease45%

see_also📖Sialorrhea and Drooling in Corticobasal Syndrome45%

see_also📖Simultanagnosia and Balint's Syndrome in Corticobasal S45%

see_also📖Sleep Disorders in Neurodegeneration45%

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see_also📖Braak Staging and Tau Propagation Pathway45%

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see_also📖Pupillometry and Chromatic Pupillometry in Corticobasal Synd45%

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see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration45%

see_also📖Cholinergic System Dysfunction in Neurodegeneration45%

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see_also📖Neural Circuits in Neurodegeneration45%

see_also📖Cognitive Reserve and Resilience in Neurodegeneration45%

see_also📖Computational Disease Models for Neurodegeneration45%

see_also📖Convergent Pathways in Neurodegeneration45%

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see_also📖Endosomal Sorting Defects in Neurodegeneration45%

see_also📖Endothelin Signaling Pathway in Neurodegeneration45%

see_also📖epigenetics-neurodegeneration45%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration45%

see_also📖FA2H-Associated Neurodegeneration Pathway45%

see_also📖FTDP-17 Clinical Phenotypes and Disease Progression45%

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see_also📖Gangliosides in Neurodegeneration45%

see_also📖GBA Glucocerebrosidase Dysfunction and Parkinson's Dise45%

see_also📖GDF15/GDF11 Signaling in Neurodegeneration45%

see_also📖GDNF Signaling Pathway in Neurodegeneration45%

see_also📖Geniposide for Alzheimer's disease - immune biomarker t45%

see_also📖Ghrelin Signaling Pathway in Neurodegeneration45%

see_also📖Glial Tau Pathology in PSP and CBD45%

see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration45%

see_also📖Glycosylation in Neurodegeneration45%

see_also📖Glymphatic Clearance Hypothesis — Impaired Aβ and Tau Remova45%

see_also📖Glymphatic and Vascular Clearance Dysfunction in 4R-Tauopath45%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration45%

see_also📖Hippocampal Neurogenesis in Neurodegeneration45%

see_also📖Histone Modification Pathways in Neurodegeneration45%

see_also📖HMGB1 Signaling in Neurodegeneration45%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration45%

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see_also📖IL-1 Signaling Pathway in Neurodegeneration45%

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see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration45%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 45%

see_also📖Iron and Neuromelanin Accumulation in PSP45%

see_also📖Kidney-Brain Neurodegeneration Axis45%

see_also📖Lipid Dysregulation in Neurodegeneration45%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration45%

see_also📖LRRK2 Kinase Activation and Endolysosomal Dysfunction in Par45%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration45%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration45%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration45%

see_also📖Metal Homeostasis in Neurodegeneration45%

see_also📖Microglial Priming Pathway in Neurodegeneration45%

see_also📖MicroRNA Dysfunction in Neurodegeneration45%

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see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration45%

see_also📖Mitochondrial Fusion in Neurodegeneration45%

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see_also📖NF-kB Signaling Pathway in Neurodegeneration45%

see_also📖Nitric Oxide Signaling in Neurodegeneration45%

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see_also📖Neuropeptide Y Signaling in Neurodegeneration45%

see_also📖NRF2 Signaling Pathway in Neurodegeneration45%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration45%

see_also📖Orexin Signaling in Neurodegeneration45%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration45%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration45%

see_also📖Paranodal Dysfunction in Neurodegeneration45%

see_also📖Paraptosis in Neurodegeneration45%

see_also📖Parthanatos in Neurodegeneration45%

see_also📖Pericyte Loss in Neurodegeneration45%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration45%

see_also📖Pesticides and Parkinson Disease (Pest-PD) — NCT0642031045%

see_also📖PKR Pathway in Neurodegeneration45%

see_also📖PPAR Signaling Pathway in Neurodegeneration45%

see_also📖Prion Diseases in Neurodegeneration45%

see_also📖Prion-Like Spread in Neurodegeneration45%

see_also📖Prion Protein Metabolism in Neurodegeneration45%

see_also📖Progesterone Signaling Pathway in Neurodegeneration45%

see_also📖Prognostic Biomarkers in Neurodegeneration45%

see_also📖Protein Aggregation Comparison in Neurodegeneration45%

see_also📖Protein Aggregation Seeds in Neurodegeneration45%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration45%

see_also📖Advanced Proteolysis and Ubiquitin System Targeting in CBS/P45%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su45%

see_also📖Gait and Balance Disorders in Progressive Supranuclear Palsy45%

see_also📖HLA Haplotypes and Neuroinflammatory Profiles in PSP45%

see_also📖PSP Liquid-Liquid Phase Separation and Biomolecular Condensa45%

see_also📖PSP Lysosomal Dysfunction and Autophagy Impairment45%

see_also📖Metabolic Dysfunction and Insulin Resistance in Progressive 45%

see_also📖Pupillary and Visual Dysfunction in Progressive Supranuclear45%

see_also📖PSP Tau Propagation and Spreading Mechanisms45%

see_also📖PSP Weight Loss and Cachexia45%

see_also📖Purinergic Signaling in Neurodegeneration45%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener45%

see_also📖R-Loop Stress in Neurodegeneration45%

see_also📖RAN Translation in Neurodegeneration45%

see_also📖Retinal Degeneration Pathway in Neurodegeneration45%

see_also📖Ribosome Dysfunction in Neurodegeneration45%

see_also📖RNA Splicing in Neurodegeneration45%

see_also📖RNA-Targeted Therapies in Neurodegeneration45%

see_also📖Ribonuclease κ and Circular RNAs: A New Mechanism of Aging a45%

see_also📖S100 Protein Signaling Pathway in Neurodegeneration45%

see_also📖Senescent Cell Clearance in Neurodegeneration45%

see_also📖Serotonergic Dysfunction in Neurodegeneration45%

see_also📖Sex Differences in Neurodegeneration45%

see_also📖Short Chain Fatty Acids in Neurodegeneration45%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration45%

see_also📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration45%

see_also📖Sleep Architecture Changes in CBS and PSP45%

see_also📖Sleep and Circadian Dysfunction in Alzheimer's Disease45%

see_also📖Sleep Dysfunction in Neurodegeneration45%

see_also📖Somatic Mutations and Brain Mosaicism45%

see_also📖Speech and Language Deficits in Corticobasal Syndrome45%

see_also📖SUMOylation in Neurodegeneration45%

see_also📖Synaptic Loss and Dysfunction Pathway45%

see_also📖synaptic-vesicle-cycling-neurodegeneration45%

see_also📖Synthetic Lethality and PARP Inhibition in Neurodegeneration45%

see_also📖Systemic Infection and Tau Pathology Acceleration45%

see_also📖T-Cell Dysfunction in Neurodegeneration45%

see_also📖Tau Seeding and Propagation Pathway45%

see_also📖TBK1 Autophagy and Neuroinflammation ALS/FTD Causal Chain45%

see_also📖Tertiary Lymphoid Organs in Neurodegeneration45%

see_also📖Therapeutic Targets in Neurodegeneration45%

see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration45%

see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration45%

see_also📖Ubiquitin-Proteasome System Dysfunction in Neurodegeneration45%

see_also📖Vagus Nerve Pathway in Neurodegeneration45%

see_also📖VEGF Signaling and Cerebral Angiogenesis in Neurodegeneratio45%

see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio45%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen45%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration45%

see_also📖ALS Therapeutic Landscape — Programs by Phase and Modality45%

mentions🔬APOE4 differs from APOE3 by C112R causing domain interaction40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu40%

related🧪RAB27A-dependent extracellular vesicle engineering for mitoc40%

related🧪LRP1-Dependent Tau Uptake Disruption40%

related🧪Low Complexity Domain Cross-Linking Inhibition40%

related🧪Glycine-Rich Domain Competitive Inhibition40%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction40%

related🧪Competitive APOE4 Domain Stabilization Peptides40%

related🧪Near-infrared light therapy stimulates COX4-dependent mitoch40%