🧫
MLCS Quantification in Parkinson's Disease
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-mlcs-qua
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.896868Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['FOXO1/MCU/MIRO1'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # MLCS Quantification in Parkinson's Disease ## Background and Rationale Mitochondria-lysosome contact sites (MLCS) represent a critical and relatively recently discovered cellular interface that orch |
| replication_status | single_study |
| methodology_notes | **Phase 1: iPSC Derivation and Dopaminergic Neuronal Differentiation** Obtain CD34+ hematopoietic stem cells or fibroblasts from 5 Parkinson's Disease patients (mean age 60±8 years, Hoehn-Yahr stage 2 |
| primary_outcome | Quantitatively characterize the structural and molecular alterations in mitochondria-lysosome contact sites that distinguish Parkinson's Disease neuronal systems from healthy neuronal controls |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.896878'} |
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