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gba

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-gba

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slug	genes-gba
entity_type	gene
kg_node_id	GBA

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Linked Artifacts (69)

mentions🔬Analysis question not specified75%

mentions🔬How to break the GBA-alpha-synuclein bidirectional loop for 75%

mentions🧫Validate Mitochondria-Lysosome Contact Site Dysfunction in P70%

mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration70%

mentions🧫Genetic Risk Modifiers in DLB Phenotype70%

mentions🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#70%

mentions🧫LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne70%

mentions🧫MLCS Quantification in Parkinson's Disease70%

mentions🧫Experiment: Multi-Ethnic PD GWAS70%

related🧫Validate Mitochondria-Lysosome Contact Site Dysfunction in P70%

related🔬Analysis question not specified67%

related🔬How to break the GBA-alpha-synuclein bidirectional loop for 67%

related🧫Autophagy Enhancement Drug Screening for Neurodegeneration63%

related🧫Genetic Risk Modifiers in DLB Phenotype63%

related🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#63%

related🧫LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne63%

related🧫MLCS Quantification in Parkinson's Disease63%

related🧫Experiment: Multi-Ethnic PD GWAS63%

see_also📖ABCD3 Gene60%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖ABCA7 (Redirect)60%

see_also📖adam1060%

see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%

see_also📖AKT1 Gene60%

mentions🧫Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio50%

mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration50%

mentions🧫Genetic Risk Modifiers in DLB Phenotype50%

mentions🧫DLB Treatment Response Biomarkers — Predicting Cholinesteras50%

mentions🧫DNA Damage Repair Deficiency Validation Study in Parkinson&#50%

mentions🧫GLP-1 Agonist Responder Prediction Study — Precision Medicin50%

mentions🧫LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne50%

mentions🧫Validate Mitochondria-Lysosome Contact Site Dysfunction in P50%

mentions🧫MLCS Quantification in Parkinson's Disease50%

mentions🧫Experiment: Multi-Ethnic PD GWAS50%

mentions🧫Prodromal Parkinson's Disease Biomarker Development — E50%

mentions🧫Synaptic Vesicle Trafficking Dysfunction Validation in Parki50%

mentions🧪Smartphone-Detected Motor Variability Correction50%

mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%

mentions🧪Stress Granule Phase Separation Modulators50%

mentions🧪Phase-Separated Organelle Targeting50%

mentions🧪RNA Granule Nucleation Site Modulation50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Lysosomal Positioning Dynamics Modulation50%

mentions🧪Mitochondrial Transfer Pathway Enhancement50%

mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation50%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy50%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪APOE-Dependent Autophagy Restoration50%

mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

mentions🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying microglia-astrocyte cross50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

related🔬Investigate prion-like spreading of tau pathology through co50%

related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%