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PINK1 — PTEN Induced Kinase 1

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-genes-pink1
Related Entities
PINK1
Metadata
sluggenes-pink1
entity_typegene
kg_node_idPINK1
Linked Artifacts (198)
related🧪PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor85%
mentions🧫s:** - Dose-response studies showing therapeutic window with70%
mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration70%
mentions🧫Selective Vulnerability of Dopaminergic Neurons — Mechanism 70%
mentions🧫Exercise-BDNF-Mitophagy Biomarker Study in PD70%
mentions🧫MLCS Quantification in Parkinson's Disease70%
mentions🧫Experiment: Multi-Ethnic PD GWAS70%
related🧫s:** - Dose-response studies showing therapeutic window with63%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration63%
related🧫Selective Vulnerability of Dopaminergic Neurons — Mechanism 63%
related🧫Exercise-BDNF-Mitophagy Biomarker Study in PD63%
related🧫MLCS Quantification in Parkinson's Disease63%
related🧫Experiment: Multi-Ethnic PD GWAS63%
mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK60%
mentions🧪PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor60%
see_also📖ABCD3 Gene60%
see_also📖AIF1 Gene60%
see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%
see_also📖ABCA7 (Redirect)60%
see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%
see_also📖ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 460%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro55%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK54%
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%
mentions🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration50%
mentions🧪VCP-Mediated Autophagy Enhancement50%
mentions🧪Senescent Cell Mitochondrial DNA Release50%
mentions🧪RAB27A-dependent extracellular vesicle engineering for mitoc50%
mentions🧪APOE-Mediated Synaptic Lipid Raft Stabilization50%
mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%
mentions🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis50%
mentions🧪Mitochondrial Transfer Pathway Enhancement50%
mentions🧪TFAM overexpression creates mitochondrial donor-recipient gr50%
mentions🧪Metabolic Switch Targeting for A1→A2 Repolarization50%
mentions🧪Partial Neuronal Reprogramming via Modified Yamanaka Cocktai50%
mentions🧪Senescence-Associated Myelin Lipid Remodeling50%
mentions🧪Selective Acid Sphingomyelinase Modulation Therapy50%
mentions🧪Near-infrared light therapy stimulates COX4-dependent mitoch50%
mentions🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%
mentions🧫s:** - Dose-response studies showing therapeutic window with50%
mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration50%
mentions🧫Selective Vulnerability of Dopaminergic Neurons — Mechanism 50%
mentions🧫Epigenetic Dysregulation Validation in Parkinson's Dise50%
mentions🧫Exercise-BDNF-Mitophagy Biomarker Study in PD50%
mentions🧫MLCS Quantification in Parkinson's Disease50%
mentions🧫Experiment: Multi-Ethnic PD GWAS50%
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%
mentions🧪Senescent Cell Mitochondrial DNA Release50%
mentions🧪RAB27A-dependent extracellular vesicle engineering for mitoc50%
mentions🧪PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor50%
mentions🧪Synthetic Biology Approach: Designer Mitochondrial Export Sy50%
mentions🧪Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption50%
mentions🧪Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy50%
mentions🧪TFAM overexpression creates mitochondrial donor-recipient gr50%
mentions🧪Microglia-Derived Extracellular Vesicle Engineering for Targ50%
mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%
mentions🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Palmitoylation-Targeted BACE1 Trafficking Disruptors50%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%
mentions🧪Microglial Efferocytosis Enhancement via GPR32 Superagonists50%
mentions🧪Optogenetic Microglial Deactivation via Engineered Inhibitor50%
mentions🧪Fractalkine Axis Amplification via CX3CR1 Positive Allosteri50%
mentions🧪Stress Granule Phase Separation Modulators50%
mentions🧪Phase-Separated Organelle Targeting50%
mentions🧪RNA Granule Nucleation Site Modulation50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition50%
mentions🧪Mitochondrial Calcium Buffering Enhancement via MCU Modulati50%
mentions🧪PARP1 Inhibition Therapy50%
mentions🧪Perforant Path Presynaptic Terminal Protection Strategy50%
mentions🧪Arginine Methylation Enhancement Therapy50%
mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%
mentions🧪Cryptic Exon Silencing Restoration50%
mentions🧪Glycine-Rich Domain Competitive Inhibition50%
mentions🧪Cross-Seeding Prevention Strategy50%
mentions🧪Magnetosonic-Triggered Transferrin Receptor Clustering50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪Synthetic Biology Approach: Designer Mitochondrial Export Sy50%
mentions🧪APOE-Dependent Autophagy Restoration50%
mentions🧪Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption50%
mentions🧪Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy50%
mentions🧪Microglia-Derived Extracellular Vesicle Engineering for Targ50%
mentions🧪Senescence-Induced Lipid Peroxidation Spreading50%
mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying astrocyte reactivity subt50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying astrocyte reactivity subt50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬What are the mechanisms underlying mechanistic role of apoe 50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying blood-brain barrier trans50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
mentions📖AD/PD 2026 Conference40%
mentions📖AD/PD 2026 Scientific Sessions40%
mentions📖Anthony H. V. Schapira40%
mentions📖CJ Healthcare40%
mentions📖Case Western Reserve University40%
mentions📖Chinese Academy of Sciences40%
mentions📖KeifeRx40%
mentions📖Kinevo Inc.40%
mentions📖Krasue Inc.40%
mentions📖Lupin Pharmaceuticals40%
mentions📖Medtronic40%
mentions📖MitoRestore Pharmaceuticals40%
mentions📖MitoThera40%
mentions📖Moscow State University40%
mentions📖NeuroMit Pharmaceuticals40%
mentions📖PD GSK3 Inhibitor Companies40%
mentions📖Peking University40%
mentions📖University of Nottingham40%
mentions📖University of Tokyo40%
mentions📖Université de Montréal40%
mentions📖Z-index Pharma40%
mentions📖Zbigniew Wszolek40%
mentions📖Zhejiang University40%
mentions📖uni-pittsburgh40%
mentions📖university-of-basel40%
mentions📖university-of-manchester40%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪Mitochondrial-Lysosomal Contact Site Engineering40%
related🧪CX43 hemichannel engineering enables size-selective mitochon40%
related🧪RAB27A-dependent extracellular vesicle engineering for mitoc40%
related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%
related🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho40%
related🧪Autophagosome Maturation Checkpoint Control40%
related🧪GAP43-mediated tunneling nanotube stabilization enhances neu40%
related🧪Lysosomal Membrane Repair Enhancement40%
related🧪Lysosomal Calcium Channel Modulation Therapy40%
related🧪TFAM overexpression creates mitochondrial donor-recipient gr40%
related🧪Transcriptional Autophagy-Lysosome Coupling40%
related🧪Lysosomal Positioning Dynamics Modulation40%
related🧪Lysosomal Enzyme Trafficking Correction40%
related🧪Near-infrared light therapy stimulates COX4-dependent mitoch40%
related🧪Mitochondrial-Lysosomal Contact Site Engineering40%
related🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration40%
related🧪VCP-Mediated Autophagy Enhancement40%
related🧪Senescent Cell Mitochondrial DNA Release40%
related🧪RAB27A-dependent extracellular vesicle engineering for mitoc40%
related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation40%
related🧪Senescence-Induced Lipid Peroxidation Spreading40%
related🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis40%
related🧪Mitochondrial Transfer Pathway Enhancement40%
related🧪TFAM overexpression creates mitochondrial donor-recipient gr40%
related🧪Metabolic Switch Targeting for A1→A2 Repolarization40%
related🧪Partial Neuronal Reprogramming via Modified Yamanaka Cocktai40%
related🧪Senescence-Associated Myelin Lipid Remodeling40%
related🧪Serine/Arginine-Rich Protein Kinase Modulation40%
related🧪Selective Acid Sphingomyelinase Modulation Therapy40%
related🧪Near-infrared light therapy stimulates COX4-dependent mitoch40%
related🧪FOXO3-Longevity Pathway Epigenetic Reprogramming40%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa40%
related🔬Multiple NDDs converge on autophagy-lysosome dysfunction. Ar40%
related🔬What are the mechanisms underlying mitochondrial transfer be40%
related🔬Mitochondrial transfer between astrocytes and neurons40%
mentions🔬What are the mechanisms underlying astrocyte reactivity subt35%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬What are the mechanisms underlying what are the mechanisms b35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬What are the mechanisms underlying protein aggregation cross35%
mentions🔬What are the mechanisms underlying mechanistic role of apoe 35%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬What are the mechanisms underlying epigenetic clocks and bio35%
mentions🔬Epigenetic reprogramming in aging neurons35%
mentions🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc35%
mentions🔬Investigate prion-like spreading of tau pathology through co35%
related🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK35%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc30%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc30%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di30%
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