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Parkinson's Disease Subtype Classification — Precision Medicine Approach
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experiment
Created: 2026-04-02T10:01:41
By: crosslink-v2
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ID: experiment-exp-wiki-experiments-pd-disea
🧫 Experiment Protocol
Clinicalproposed
SUMMARY
# Parkinson's Disease Subtype Classification — Precision Medicine Approach
## Background and Rationale
Parkinson's disease (PD) presents with remarkable clinical and biological heterogeneity, yet current diagnostic and therapeutic approaches treat it as a uniform condition. This heterogeneity manifests in variable motor and non-motor symptoms, differential rates of progression, and inconsistent treatment responses across patients. Recent advances in multi-omics technologies, neuroimaging, and di
METHODOLOGY NOTES
Phase 1 (Months 1-6): Recruit 800 participants including 600 PD patients (300 newly diagnosed, 300 established) and 200 age-matched controls from 10 movement disorder centers. Inclusion criteria: clinical PD diagnosis per MDS criteria, age 50-80, Hoehn-Yahr stages 1-3. Exclusion criteria: atypical parkinsonism, dementia (MoCA <24), significant comorbidities.
Phase 2 (Months 3-18): Comprehensive baseline assessment including MDS-UPDRS motor and non-motor evaluations, cognitive testing battery (MoCA, detailed neuropsychological assessment), DaTscan SPECT imaging, 3T MRI with structural, diffusion tensor, and resting-state functional sequences, collection of blood and CSF samples for multi-omics analysis, and deployment of wearable devices (smartwatch, smartphone) for 2-week continuous monitoring periods.
Phase 3 (Months 6-24): Process biological samples using standardized protocols for proteomics (TMT mass spectrometry), metabolomics (LC-MS/MS), and transcriptomics (RNA-seq). Analyze d
▸Metadatasource: {'type': 'manual', 'source_name': 'wiki'
| source | {'type': 'manual', 'source_name': 'wiki', 'extracted_by': 'backfill_v1', 'extraction_date': '2026-04-16T01:00:16.901397Z'} |
| summary | # Parkinson's Disease Subtype Classification — Precision Medicine Approach ## Background and Rationale Parkinson's disease (PD) presents with remarkable clinical and biological heterogeneity, yet curr |
| entities | {'genes': ['CLDN1/DNMT1/DRD2'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| _schema_version | 1 |
| experiment_type | clinical |
| primary_outcome | Validate Parkinson's Disease Subtype Classification — Precision Medicine Approach |
| methodology_notes | Phase 1 (Months 1-6): Recruit 800 participants including 600 PD patients (300 newly diagnosed, 300 established) and 200 age-matched controls from 10 movement disorder centers. Inclusion criteria: clin |
| replication_status | single_study |
| extraction_metadata | {'backfill_at': '2026-04-16T01:00:16.901402', 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'extraction_confidence': 0.4} |
📊 Evidence Profile
Foundational
Evidence Balance
+0%
Certainty
100%
Debates
0
Incoming
735
Outgoing
660
0 supporting
0 contradicting
0 neutral
🌍 Provenance Graph
9 nodes, 37 edges
derives from (16)
experiment-exp-wiki-experiment→hypothesis-h-072b2f5dhypothesis-h-072b2f5d→analysis-SDA-2026-04-01-gap-01analysis-SDA-2026-04-01-gap-01→hypothesis-h-b0cda336analysis-SDA-2026-04-01-gap-01→hypothesis-h-072b2f5dexperiment-exp-wiki-experiment→hypothesis-h-74777459
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hypothesis-h-74777459→analysis-SDA-2026-04-01-gap-20analysis-SDA-2026-04-01-gap-20→hypothesis-h-6c83282danalysis-SDA-2026-04-01-gap-20→hypothesis-h-74777459analysis-SDA-2026-04-01-gap-20→hypothesis-h-2e7eb2eaexperiment-exp-wiki-experiment→hypothesis-h-2e7eb2eahypothesis-h-2e7eb2ea→analysis-SDA-2026-04-01-gap-20experiment-exp-wiki-experiment→hypothesis-h-b0cda336hypothesis-h-b0cda336→analysis-SDA-2026-04-01-gap-01experiment-exp-wiki-experiment→hypothesis-h-6c83282dhypothesis-h-6c83282d→analysis-SDA-2026-04-01-gap-20experiment-exp-wiki-experiment→wiki-experiments-pd-disease-su
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