Gut Barrier Permeability-α-Synuclein Axis Modulation

**Molecular Mechanism and Rationale** The gut-brain axis represents a critical bidirectional communication pathway that has emerged as a central player in neurodegenerative disease pathogenesis, particularly in α-synucleinopathies such as Parkinson's disease. The molecular foundation of this hypothesis centers on the compromised intestinal barrier integrity mediated by dysbiotic microbial communities and their direct impact on α-synuclein pathology propagation. The intestinal epithelial barrier...