Thalamocortical Feedforward Inhibition Imposes Rhythm on Glymphatic Waste Clearance Windows

graph TD
    GluN2B["GluN2B"] -->|regulates| thalamic_burst_firing["thalamic burst firing"]
    slow_wave_oscillations["slow-wave oscillations"] -->|enhances| glymphatic_clearance["glymphatic_clearance"]
    tau_pathology["tau_pathology"] -.->|inhibits| glymphatic_clearance_effi["glymphatic clearance efficiency"]
    Trem2["Trem2"] -->|regulates| tau_phagocytosis["tau phagocytosis"]
    TREM2_deficiency["TREM2 deficiency"] -->|associated with| Tau_Clearance["Tau Clearance"]
    Cx3Cl1["Cx3Cl1"] -->|associated with| Cx3Cr1["Cx3Cr1"]
    Cx3Cr1_1["Cx3Cr1"] -->|regulates| tau_phagocytosis_2["tau phagocytosis"]
    Memantine["Memantine"] -->|enhances| CSF_tracer_clearance["CSF tracer clearance"]
    GluN2B_3["GluN2B"] -->|associated with| cortical_slow_wave_oscill["cortical slow-wave oscillations"]
    oxidative_stress["oxidative_stress"] -->|causes| AQP4_oxidation["AQP4 oxidation"]
    GLUTAMATE_EXCITOTOXICITY["GLUTAMATE EXCITOTOXICITY"] -->|enhances| Tau_Secretion["Tau Secretion"]
    sess_SRB_2026_04_28_h_var["sess_SRB-2026-04-28-h-var-e2b5a7e7db_task_9aae8fc5"] -->|causal extracted| processed["processed"]
    style GluN2B fill:#4fc3f7,stroke:#333,color:#000
    style thalamic_burst_firing fill:#4fc3f7,stroke:#333,color:#000
    style slow_wave_oscillations fill:#4fc3f7,stroke:#333,color:#000
    style glymphatic_clearance fill:#81c784,stroke:#333,color:#000
    style tau_pathology fill:#ef5350,stroke:#333,color:#000
    style glymphatic_clearance_effi fill:#4fc3f7,stroke:#333,color:#000
    style Trem2 fill:#4fc3f7,stroke:#333,color:#000
    style tau_phagocytosis fill:#4fc3f7,stroke:#333,color:#000
    style TREM2_deficiency fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Clearance fill:#4fc3f7,stroke:#333,color:#000
    style Cx3Cl1 fill:#4fc3f7,stroke:#333,color:#000
    style Cx3Cr1 fill:#4fc3f7,stroke:#333,color:#000
    style Cx3Cr1_1 fill:#4fc3f7,stroke:#333,color:#000
    style tau_phagocytosis_2 fill:#4fc3f7,stroke:#333,color:#000
    style Memantine fill:#ce93d8,stroke:#333,color:#000
    style CSF_tracer_clearance fill:#ce93d8,stroke:#333,color:#000
    style GluN2B_3 fill:#4fc3f7,stroke:#333,color:#000
    style cortical_slow_wave_oscill fill:#4fc3f7,stroke:#333,color:#000
    style oxidative_stress fill:#4fc3f7,stroke:#333,color:#000
    style AQP4_oxidation fill:#4fc3f7,stroke:#333,color:#000
    style GLUTAMATE_EXCITOTOXICITY fill:#4fc3f7,stroke:#333,color:#000
    style Tau_Secretion fill:#4fc3f7,stroke:#333,color:#000
    style sess_SRB_2026_04_28_h_var fill:#4fc3f7,stroke:#333,color:#000
    style processed fill:#4fc3f7,stroke:#333,color:#000