gene

CX3CL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CX3CL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

489Connections

4Hypotheses

5Analyses

50Outgoing

50Incoming

0Experiments

9Debates

Summary

Page for CX3CL1 — Fractalkine (C-X3-C Motif Chemokine Ligand 1)

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🧬 Gene Info

Gene Symbol	CX3CL1
Full Name	Fractalkine (C-X3-C Motif Chemokine Ligand 1)
Aliases	C-X3-C Motif Chemokine Ligand 1
Chromosome	16q13
Primary Expression	Neurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids	373 aa
Pathways	Neuroinflammatory
UniProt ID	P78423
NCBI Gene ID	6376
Ensembl ID	ENSG00000006210
OMIM	601880
GeneCards	CX3CL1
Human Protein Atlas	CX3CL1
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections	484 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CX3CL1 — AlphaFold P78423 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    CX3CL1 -->|"regulates"| Inflammation["Inflammation"]
    CX3CL1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CX3CL1 -->|"target for"| Aging["Aging"]
    CX3CL1 -->|"interacts"| Ms["Ms"]
    CX3CL1 -.biomarker for.-> Senescence["Senescence"]
    CX3CL1 -.biomarker for.-> Als["Als"]
    CX3CL1 -.biomarker for.-> Longevity["Longevity"]
    CX3CR1["CX3CR1"] -->|"target for"| CX3CL1
    FGF21["FGF21"] -->|"activates"| CX3CL1
    APP["APP"] -.biomarker for.-> CX3CL1
    FNDC5["FNDC5"] -->|"activates"| CX3CL1
    S100B["S100B"] -.biomarker for.-> CX3CL1
    PLAU["PLAU"] -->|"activates"| CX3CL1
    CXCL10["CXCL10"] -->|"activates"| CX3CL1
    C1Q["C1Q"] -.biomarker for.-> CX3CL1
    OVERVIEW["OVERVIEW"] -->|"expressed in"| CX3CL1
    FGF23["FGF23"] -->|"activates"| CX3CL1

Outgoing (341)

Target	Relation	Type	Str
Neurons	interacts_with	cell_type	0.95
Fractalkine	associated_with	protein	0.95
Frailty	biomarker_for	phenotype	0.95
Cx3Cr1	binds	protein	0.95
Neuroinflammation	modulates	process	0.95
Microglial activation	modulates	process	0.90
Blood-Brain Barrier	regulates	brain_region	0.90
Microglia	interacts_with	cell_type	0.90
Neuron-Glial Signaling	mediates	pathway	0.90
CX3CR1/AMPK/PPARG Pathway	activates	pathway	0.90
Neuron-Glial Signaling	involved_in	pathway	0.90
NEURON	expressed_in	cell_type	0.90
Neurons	expressed_in	cell_type	0.90
Hematoma Resolution	associated_with	process	0.85
Neurodegeneration	targets	disease	0.85
Frailty	biomarker_for	phenotype	0.85
Germinal Matrix Hemorrhage	protects_against	disease	0.85
neurodegeneration	associated_with	process	0.85
Neurodegenerative Diseases	therapeutic_target	disease	0.85
neurodegenerative disease	implicated_in	disease	0.80
neurodegenerative diseases	targets	disease	0.80
GNB5	regulates	protein	0.80
microglia	expressed_in	cell_type	0.80
Inflammation	activates	disease	0.75
CX3CR1	expressed_in	gene	0.70
NEURONS	expressed_in	cell_type	0.70
NEURONS	activates	cell_type	0.70
NEURONS	mediates	cell_type	0.70
CXCL10	biomarker_for	gene	0.70
MICROGLIA	expressed_in	cell_type	0.70
NEURONS	transports	cell_type	0.70
STAT3	activates	gene	0.70
TREM2	associated_with	gene	0.70
MICROGLIA	transports	cell_type	0.70
MICROGLIA	mediates	cell_type	0.70
MICROGLIA	regulates	cell_type	0.70
CX3CR1	transports	gene	0.70
STING	biomarker_for	gene	0.70
MACROPHAGE	disrupts	cell_type	0.70
ENDOTHELIAL	targets	cell_type	0.70
MACROPHAGE	targets	cell_type	0.70
MACROPHAGE	interacts_with	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
microglial activation	modulates	mechanism	0.70
motor neuron survival	protective_against	process	0.70
microglia	modulates	cell_type	0.70
neurons	expressed_in	cell_type	0.70
Cx3Cr1	associated_with	protein	0.70
Tauopathy	inhibits	disease	0.65
Dementia	inhibits	disease	0.65

Incoming (148)

Source	Relation	Type	Str
Repetitive Transcranial Magnetic Stimulation	upregulates	drug	0.92
GABAergic Neuron	produces	cell_type	0.90
h-494861d2	targets	hypothesis	0.90
miR-16-5p	downregulates	biomarker	0.85
miR-125b-5p	downregulates	biomarker	0.85
ADAM10	regulates	gene	0.70
CCL2	regulates	gene	0.70
ASTROCYTE	reduces	cell_type	0.65
APP/PS1	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
CANCER	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
ASTROCYTES	activates	gene	0.60
DIABETIC RETINOPATHY	activates	gene	0.60
MICROGLIA	interacts_with	gene	0.60
NF-ΚB	inhibits	gene	0.60
AD	co_discussed	gene	0.60
INFLAMMATION	activates	gene	0.60
WNT	inhibits	gene	0.60
TAUOPATHY	inhibits	gene	0.60
AGING	therapeutic_target	gene	0.60
AMYLOID	inhibits	gene	0.60
CX3CR1	expressed_in	gene	0.60
SYNAPSE	inhibits	gene	0.60
CXCL10	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
CXCR1	associated_with	gene	0.60
OVERVIEW	expressed_in	gene	0.60
FGF23	activates	gene	0.60
GPNMB	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
RAGE	activates	gene	0.60
LGALS3	activates	gene	0.60
BLM	activates	gene	0.60
CCL20	regulates	gene	0.60
STAT3	regulates	gene	0.60
CTSB	activates	gene	0.60
CTSL	activates	gene	0.60
CTSS	activates	gene	0.60
JAK2	activates	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GluN2B-CX3CL1 Axis Controls Microglial Tau Phagocytosis	0.761	neuroscience	GluN2B-Mediated Thalamocortical Control
CX3CL1-CX3CR1 Mimetic Therapy for Neuroprotection	0.635	neurodegeneration	Microglial subtypes in neurodegeneration
Soluble CX3CL1 cleavage by ADAM proteases disengages fractal	0.540	neurodegeneration	Synaptic pruning by microglia in neurode
CX3CL1 Mimetic Peptide to Disrupt Fractalkine Signaling Dysr	0.459	immunomics	Systemic immune profiling in neurodegene

Mentioning Analyses (5)

Scientific analyses that reference this entity

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

neuroscience | 2026-04-28 | 7 hypotheses Top: 0.808

TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers

neurodegeneration | 2026-04-26 | 8 hypotheses Top: 0.861

Microglial subtypes in neurodegeneration — friend vs foe

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.685

What are the molecular signatures that distinguish protective vs. harmful microg

neurodegeneration | 2026-04-12 | 0 hypotheses

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (9)

Multi-agent debates referencing this entity

Structured research brief for hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thala

active · Rounds: 4 · Score: 0.82 · 2026-04-28

Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegenera

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Hypothesis debate: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular T

closed · Rounds: 4 · Score: 0.50 · 2026-04-27

Hypothesis debate: TREM2-Dependent Microglial Senescence Transition

closed · Rounds: 4 · Score: 0.64 · 2026-04-26

Hypothesis debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegene

closed · Rounds: 4 · Score: 0.50 · 2026-04-26

What are the key mechanistic, therapeutic, and diagnostic dimensions of TREM2 in

closed · Rounds: 4 · Score: 0.92 · 2026-04-26

The debate transcript shows incomplete information exchange, suggesting this fun

closed · Rounds: 4 · Score: 0.49 · 2026-04-18

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Synaptic pruning by microglia in early AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning CX3CL1 in their description or question text

No additional research found

CX3CL1

Understanding Entity Pages

Summary

Wiki Pages (3)

Fractalkine (CX3CL1) - Neuroinflammation Biomarker

CX3CL1 (Fractalkine) Protein

CX3CL1 — Fractalkine (C-X3-C Motif Chemokine Ligand 1)

Pathway Diagram

Outgoing (341)

Incoming (148)

Targeting Hypotheses (4)

Mentioning Analyses (5)

GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance

TREM2 in Alzheimer's Disease: Mechanisms, Therapeutics, and Biomarkers

Microglial subtypes in neurodegeneration — friend vs foe

What are the molecular signatures that distinguish protective vs. harmful microg

Synaptic pruning by microglia in early AD

Experiments (0)

Related Papers (0)

Debates (9)

Structured research brief for hypothesis h-var-e2b5a7e7db: GluN2B-Mediated Thala

Extended debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegenera

Hypothesis debate: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular T

Hypothesis debate: TREM2-Dependent Microglial Senescence Transition

Hypothesis debate: TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegene

What are the key mechanistic, therapeutic, and diagnostic dimensions of TREM2 in

The debate transcript shows incomplete information exchange, suggesting this fun

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

Synaptic pruning by microglia in early AD

Related Research