📄
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-23143307
📄 Paper Details
8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.
["Sheng Z", "Oka S", "Tsuchimoto D", "Abolhassani N", "Nomaru H", "Sakumi K", "Yamada H", "Nakabeppu Y"]
Abstract
8-Oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species, is associated with carcinogenesis and neurodegeneration. Although the mechanism by which 8-oxoG causes carcinogenesis is well understood, the mechanism by which it causes neurodegeneration is unknown. Here, we report that neurodegeneration is triggered by MUTYH-mediated excision repair of 8-oxoG-paired adenine. Mutant mice lacking 8-oxo-2'-deoxyguanosine triphosphate-depleting (8-oxo-dGTP-depleting) MTH1 and/or 8-oxoG-...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.