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Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.
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ID: paper-31611390
📄 Paper Details
Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.
["L\u00e1zaro S", "P\u00e9rez-Crespo M", "Lorz C", "Bernardini A", "Oteo M", "Enguita A", "Romero E", "Hern\u00e1ndez P", "Tom\u00e1s L", "Morcillo M"]
Abstract
High-grade neuroendocrine lung malignancies (large-cell neuroendocrine cell carcinoma, LCNEC, and small-cell lung carcinoma, SCLC) are among the most deadly lung cancer conditions with no optimal clinical management. The biological relationships between SCLC and LCNEC are still largely unknown and a current matter of debate as growing molecular data reveal high heterogeneity with potential therapeutic consequences. Here we describe murine models of high-grade neuroendocrine lung carcinomas gener...
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