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Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling.
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ID: paper-41922367
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Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling.
Dauben H, Mihaljević M, Kolvenbach A, Palumbieri MD, Kapsali C et al.
Abstract
ADP-ribosylation has long been recognised as a key regulator of essential signalling pathways, including the DNA damage response. However, only recent and ongoing technological advances are beginning to make it possible to investigate its distinct forms with molecular precision. Here, we design a 'mono-ADP-ribosylation blocking' strategy to develop sensitive, modular antibodies with high specificity for poly(ADP-ribosyl)ation. During peptide antigen generation, we identify a distinctive mass spe...
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