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Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
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ID: paper-33387580
📄 Paper Details
Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases.
["Thapa K", "Khan H", "Sharma U", "Grewal A", "Singh T"]
Abstract
AIMS: Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+ depletion resulted PARP related cell death only happened when the trial used extreme high oxidization treatment. Inhibition of PARP1/2 may induce replication related cell death due ...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
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Outgoing
1
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0 contradicting
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