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Effective oral countermeasures against ionizing radiation-induced damage without hindering cancer radiotherapy.
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ID: paper-41946301
📄 Paper Details
Effective oral countermeasures against ionizing radiation-induced damage without hindering cancer radiotherapy.
López-Blanch R, Oriol-Caballo M, Salvador-Palmer R, Moreno-Murciano P, Benlloch M et al.
Abstract
High-dose ionizing radiation induces severe multi-organ injury, yet no broadly effective, orally available countermeasure has been validated. Here we describe a fully oral, multi-component formulation comprising bioavailable polyphenol derivatives (pterostilbene cocrystals and silybin-phosphatidylcholine), the NAD⁺ precursor nicotinamide riboside, and captopril, an angiotensin-converting enzyme inhibitor with established radiomitigative activity that synergizes with the polyphenols. This combina...
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📊 Evidence Profile
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+0%
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5%
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