FOS Gene

FOS Gene

Introduction

Fos Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

--- [@herdegen1995]
title: FOS Gene [@dragunow1999]
description: Gene information for FBJ Murine Osteosarcoma Viral Oncogene Homolog and its role in neurodegenerative diseases [@nih]

--- [@riedel]

<div class="infobox infobox-gene">
<table>
<tr><th colspan="2" style="background:#f0f0f0; text-align:center;">FOS Gene</th></tr>
<tr><td><b>Full Name</b></td><td>FBJ Murine Osteosarcoma Viral Oncogene Homolog</td></tr>
<tr><td><b>Chromosome</b></td><td>14q24.3</td></tr>
<tr><td><b>NCBI Gene ID</b></td><td><a href="https://www.ncbi.nlm.nih.gov/gene/2353" target="_blank">2353</a></td></tr>
<tr><td><b>OMIM</b></td><td><a href="https://www.omim.org/entry/164810" target="_blank">164810</a></td></tr>
<tr><td><b>Ensembl ID</b></td><td><a href="https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170345" target="_blank">ENSG00000170345</a></td></tr>
<tr><td><b>UniProt ID</b></td><td><a href="https://www.uniprot.org/uniprot/P01100" target="_blank">P01100</a></td></tr>
<tr><td><b>Encoded Protein</b></td><td>[FOS](/proteins/fos)</td></tr>
<tr><td><b>Associated Diseases</b></td><td>[Alzheimer's disease](/diseases/alzheimers-disease), [Parkinson's disease](/diseases/parkinsons-disease), various cancers</td></tr>
</table>
</div>

Overview

FOS Gene

Introduction

Fos Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

--- [@herdegen1995]
title: FOS Gene [@dragunow1999]
description: Gene information for FBJ Murine Osteosarcoma Viral Oncogene Homolog and its role in neurodegenerative diseases [@nih]

--- [@riedel]

<div class="infobox infobox-gene">
<table>
<tr><th colspan="2" style="background:#f0f0f0; text-align:center;">FOS Gene</th></tr>
<tr><td><b>Full Name</b></td><td>FBJ Murine Osteosarcoma Viral Oncogene Homolog</td></tr>
<tr><td><b>Chromosome</b></td><td>14q24.3</td></tr>
<tr><td><b>NCBI Gene ID</b></td><td><a href="https://www.ncbi.nlm.nih.gov/gene/2353" target="_blank">2353</a></td></tr>
<tr><td><b>OMIM</b></td><td><a href="https://www.omim.org/entry/164810" target="_blank">164810</a></td></tr>
<tr><td><b>Ensembl ID</b></td><td><a href="https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170345" target="_blank">ENSG00000170345</a></td></tr>
<tr><td><b>UniProt ID</b></td><td><a href="https://www.uniprot.org/uniprot/P01100" target="_blank">P01100</a></td></tr>
<tr><td><b>Encoded Protein</b></td><td>[FOS](/proteins/fos)</td></tr>
<tr><td><b>Associated Diseases</b></td><td>[Alzheimer's disease](/diseases/alzheimers-disease), [Parkinson's disease](/diseases/parkinsons-disease), various cancers</td></tr>
</table>
</div>

Overview

The FOS gene (FBJ Murine Osteosarcoma Viral Oncogene Homolog) encodes a component of the AP-1 transcription factor complex. FOS is induced rapidly in response to neuronal activity, stress, and growth factors. It plays roles in neuronal differentiation, synaptic plasticity, and [apoptosis](/entities/apoptosis). FOS expression is altered in Alzheimer's disease, Parkinson's disease, and various neuropsychiatric conditions.

Function

FOS is an immediate-early gene encoding a leucine zipper transcription factor. It dimerizes with JUN proteins to form the AP-1 complex, which regulates genes involved in cell proliferation, differentiation, and neuronal activity.

Expression

Immediate-early gene rapidly induced in [neurons](/entities/neurons) by synaptic activity, growth factors, and stress. Expressed throughout brain, with patterns that reflect neuronal activation.

Disease Associations

FOS expression is altered in Alzheimer's disease and Parkinson's disease. It serves as a marker of neuronal activity and is used in mapping studies. Dysregulated FOS expression may reflect and contribute to network dysfunction in neurodegeneration.

Key Publications

Molecular Mechanisms

FOS (FBJ murine osteosarcoma viral oncogene homolog) is an immediate early gene that dimerizes with JUN proteins to form AP-1 transcription factor complexes. FOS is rapidly induced in neurons by synaptic activity, growth factors, and stress.

Key FOS mechanisms include:

• Activity-dependent transcription: Responds to neuronal firing and calcium influx
• AP-1 complex formation: Heterodimers with JUN family proteins (c-JUN, JUNB, JUND)
• Synaptic plasticity: Regulates genes involved in dendritic remodeling
• Stress response: Activated by oxidative stress, excitotoxicity, and neuroinflammation

Therapeutic Implications

FOS-targeted approaches:

Research Directions

Active research areas:

• FOS in Alzheimer's disease: relationship to amyloid pathology and cognitive decline
• FOS in Parkinson's disease: dopaminergic neuron activity markers
• FOS and epilepsy: FOS as a marker for seizure activity
• AP-1 complexes in neurodegeneration and neuroprotection

Background

The study of Fos Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

Brain Atlas Resources

• [Allen Human Brain Atlas - FOS Gene Expression](https://human.brain-map.org/microarray/search/show?search_term=fos)
• [Allen Cell Type Atlas - FOS Gene](https://celltypes.brain-map.org/)
• [Allen Mouse Brain Atlas - FOS Gene](https://mouse.brain-map.org/)
• [BrainSpan - FOS Gene Developmental Expression](https://brainspan.org/)

Molecular Mechanisms

FOS (FBJ murine osteosarcoma viral oncogene homolog) is an immediate early gene that dimerizes with JUN proteins to form AP-1 transcription factor complexes. FOS is rapidly induced in neurons by synaptic activity, growth factors, and stress.

Key FOS mechanisms include:

• Activity-dependent transcription: Responds to neuronal firing and calcium influx
• AP-1 complex formation: Heterodimers with JUN family proteins (c-JUN, JUNB, JUND)
• Synaptic plasticity: Regulates genes involved in dendritic remodeling
• Stress response: Activated by oxidative stress, excitotoxicity, and neuroinflammation

Therapeutic Implications

FOS-targeted approaches:

Research Di

• AP-1 complexes in neurodegeneration and neuroprotection

Brain Atlas Resources

• [Allen Human Brain Atlas - FOS Gene Expression](https://human.brain-map.org/microarray/search/show?search_term=fos)
• [Allen Cell Type Atlas - FOS Gene](https://celltypes.brain-map.org/)
• [Allen Mouse Brain Atlas - FOS Gene](https://mouse.brain-map.org/)
• [BrainSpan - FOS Gene Developmental Expression](https://brainspan.org/)

References

[@riedel]: Riedel G, e## See Also

• [Proteins Index](/proteins)
• [Genes Index](/genes)
• [Alzheimer's Disease](/diseases/alzheimers-disease) Parkinson's Disease
• [Huntington's Disease](/diseases/huntingtons-disease)
• Synaptic Dysfuncti

External Links

• [NC- [UniProt: FOS](https://www.uniprot.org/uniprot/P01100)
• [Ensembl: FOS](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170345)

Pathway Diagram

Pathway Diagram

The following diagram shows the key molecular relationships involving FOS Gene discovered through SciDEX knowledge graph analysis: