NLRP6 - NLR Family Pyrin Domain Containing 6

NLRP6 - NLR Family Pyrin Domain Containing 6

Overview

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">NLRP6 - NLR Family Pyrin Domain Containing 6</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>NLRP6</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>NLR Family Pyrin Domain Containing 6</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>11p15.5</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>171080</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>609651</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000174892</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>Q86XR5</td>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">NLRP6 inhibitors</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">NLRP6 modulators</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/autoimmune" style="color:#ef9a9a">Autoimmune</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/glioblastoma" style="color:#ef9a9a">Glioblastoma</a>, <a href="/wiki/infection" style="color:#ef9a9a">Infection</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">51 edges</a></td>
</tr>
</table>

NLRP6 - NLR Family Pyrin Domain Containing 6

Overview

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">NLRP6 - NLR Family Pyrin Domain Containing 6</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>NLRP6</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>NLR Family Pyrin Domain Containing 6</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>11p15.5</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>171080</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>609651</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000174892</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>Q86XR5</td>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">NLRP6 inhibitors</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">NLRP6 modulators</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/autoimmune" style="color:#ef9a9a">Autoimmune</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/glioblastoma" style="color:#ef9a9a">Glioblastoma</a>, <a href="/wiki/infection" style="color:#ef9a9a">Infection</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">51 edges</a></td>
</tr>
</table>

Nlrp6 Nlr Family Pyrin Domain Containing 6 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Nlrp6 Nlr Family Pyrin Domain Containing 6 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@nlrp]

NLRP6 is a member of the NOD-like receptor family, primarily known for its role in innate immunity and inflammasome assembly. It is highly expressed in intestinal epithelial cells and also in the brain. [@wnt]

Gene Overview

Function

NLRP6 plays diverse roles in immunity and metabolism:

• Inflammasome assembly: Forms inflammasome with ASC and caspase-1
• Cytokine production: Regulates IL-1β and IL-18 production
• Gut homeostasis: Critical for intestinal epithelial cell function
• [Microbiome](/entities/microbiome) modulation: Shapes gut microbiota composition
• [Autophagy](/entities/autophagy): Regulates autophagic flux

Disease Associations

Alzheimer's Disease

• NLRP6 inflammasome is activated in AD models
• Contributes to neuroinflammation through microglial activation
• NLRP6 deficiency reduces [Aβ](/proteins/amyloid-beta) pathology in mouse models

Parkinson's Disease

• NLRP6 inflammasome contributes to dopaminergic neuron inflammation
• Activation in [microglia](/entities/microglia) surrounding Lewy bodies
• Therapeutic target: NLRP6 inhibitors may reduce neuroinflammation

Inflammatory Bowel Disease

• NLRP6 mutations associated with IBD susceptibility
• Important for [gut-brain axis](/entities/gut-brain-axis) in neurodegeneration

Expression Pattern

• Brain: Expressed in [neurons](/entities/neurons), [astrocytes](/entities/astrocytes), and [microglia](/cell-types/microglia-neuroinflammation)
• Highest expression: Intestinal epithelium
• Immune cells: Monocytes, macrophages

Therapeutic Targeting

Key Publications

See Also

• [NLRP3 Gene](/proteins/nlrp3-protein)
• [NLRP1 Gene](/proteins/nlrp1-protein)
• [Neuroinflammation Pathway](/mechanisms/neuroinflammation-pathway)

External Links

• [NCBI Gene: NLRP6](https://www.ncbi.nlm.nih.gov/gene/171080)
• [UniProt: NLRP6](https://www.uniprot.org/uniprot/Q86XR5)

Overview

Nlrp6 Nlr Family Pyrin Domain Containing 6 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Nlrp6 Nlr Family Pyrin Domain Containing 6 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

Pathway Diagram

The following diagram shows the key molecular relationships involving NLRP6 - NLR Family Pyrin Domain Containing 6 discovered through SciDEX knowledge graph analysis: