gene 574 words KG: NLRP6 2026-03-21
kind:genesection:genesstate:published
Contents

NLRP6 - NLR Family Pyrin Domain Containing 6

🧬 Gene Info
Gene SymbolNLRP6
Full NameNLR Family Pyrin Domain Containing 6
AliasesPage for NLRP6, Page for NLRP6 Protein, NACHT, LRR and PYD Domains-Containing Protein 6
Chromosome11p15.5
Protein TypeReceptor
FunctionMucus Secretion: NLRP6 regulates goblet cell mucus granule exocytosis and maintains the mucus barrier[@birchenough2016].
Molecular Weight98 kDa
Amino Acids892 aa
Pathwayswnt
UniProt IDQ86XR5
NCBI Gene ID171080
Ensembl IDENSG00000174892
OMIM609651
GeneCardsNLRP6
Human Protein AtlasNLRP6
Associated DiseasesALS, Aging, Alzheimer, Autoimmune, Autoimmune Disease, Carcinoma
InteractionsAKT, OPTN, PTEN, NLRP7, NLRP12, CARD8
KG Connections162 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: regulates
Dementia Australia
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: interacts_with

Knowledge Graph (12 edges)

NLRP6 interacts_with AKT
NLRP6 activates OPTN
NLRP6 activates PTEN
NLRP6 activates NLRP7
NLRP6 activates NLRP12
NLRP6 activates CARD8
NLRP6 interacts_with PI3K
NLRP6 activates NLRP1
NLRP6 regulates NF-κB signaling
NLRP6 facilitates_degradation_via_TRIM21 TAB1