gene

NLRP6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for NLRP6 - NLR Family Pyrin Domain Containing 6

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🧬 Gene Info

Gene Symbol	NLRP6
Full Name	NLR Family Pyrin Domain Containing 6
Aliases	Page for NLRP6, Page for NLRP6 Protein, NACHT, LRR and PYD Domains-Containing Protein 6
Chromosome	11p15.5
Protein Type	Receptor
Function	Mucus Secretion: NLRP6 regulates goblet cell mucus granule exocytosis and maintains the mucus barrier[@birchenough2016].
Molecular Weight	98 kDa
Amino Acids	892 aa
Pathways	wnt
UniProt ID	Q86XR5
NCBI Gene ID	171080
Ensembl ID	ENSG00000174892
OMIM	609651
GeneCards	NLRP6
Human Protein Atlas	NLRP6
Associated Diseases	ALS, Aging, Alzheimer, Autoimmune, Autoimmune Disease, Carcinoma
Interactions	AKT, OPTN, PTEN, NLRP7, NLRP12, CARD8
KG Connections	162 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NLRP6["<b>NLRP6</b>"]
    Cancer{"Cancer"}
    NLRP6 -->|"interacts with"| Cancer
    Tumor{"Tumor"}
    NLRP6 -->|"therapeutic target"| Tumor
    Glioblastoma{"Glioblastoma"}
    NLRP6 -->|"inhibits"| Glioblastoma
    AKT["AKT"]
    NLRP6 -->|"interacts with"| AKT
    OPTN["OPTN"]
    NLRP6 -->|"activates"| OPTN
    CANCER["CANCER"]
    NLRP6 -->|"interacts with"| CANCER
    PTEN["PTEN"]
    NLRP6 -->|"activates"| PTEN
    AUTOPHAGY["AUTOPHAGY"]
    NLRP6 -->|"therapeutic target"| AUTOPHAGY
    Autophagy(["Autophagy"])
    NLRP6 -->|"therapeutic target"| Autophagy
    Innate_Immunity(["Innate Immunity"])
    NLRP6 -->|"interacts with"| Innate_Immunity
    Akt(["Akt"])
    NLRP6 -->|"interacts with"| Akt
    Pi3K(["Pi3K"])
    NLRP6 -->|"interacts with"| Pi3K
    PI3K["PI3K"]
    PI3K -->|"interacts with"| NLRP6
    style NLRP6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (112)

Target	Relation	Type	Str
NF-κB signaling	regulates	pathway	0.95
TAB1	facilitates_degradation_via_TRIM21	protein	0.93
sepsis	protects_against	disease	0.90
NAFLD/NASH	inhibits	disease	0.90
Nlrp Inflammasomes	involved_in	protein	0.85
pyroptosis	participates_in	pathway	0.80
Autoimmune Disease	associated_with	disease	0.75
Cancer	interacts_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	inhibits	disease	0.65
Infection	regulates	disease	0.65
Autoimmune	implicated_in	disease	0.65
Ms	activates	disease	0.65
Autoimmune	activates	disease	0.65
Pyroptosis	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	regulates	disease	0.65
Obesity	regulates	disease	0.65
Carcinoma	causes	disease	0.65
Obesity	causes	disease	0.65
Cirrhosis	causes	disease	0.65
Hepatitis	causes	disease	0.65
Hypertension	causes	disease	0.65
ALS	causes	disease	0.65
Inflammation	causes	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Hypertension	regulates	disease	0.65
Pyroptosis	interacts_with	disease	0.65
AKT	interacts_with	gene	0.60
OPTN	activates	gene	0.60
PTEN	activates	gene	0.60
NLRP7	activates	gene	0.60
NLRP12	activates	gene	0.60
CARD8	activates	gene	0.60
PI3K	interacts_with	gene	0.60
NLRP1	activates	gene	0.60
NLRP2	activates	gene	0.60
NLRP3	activates	gene	0.60
NLRP3	associated_with	gene	0.60
CASP4	associated_with	gene	0.60
CASP6	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
BAX	associated_with	gene	0.60
TLR9	regulates	gene	0.60
TNF	regulates	gene	0.60
NLRP3	regulates	gene	0.60
GAIN	activates	gene	0.60
TLR4	causes	gene	0.60

Incoming (50)

Source	Relation	Type	Str
PI3K	interacts_with	gene	0.60
NLRP3	activates	gene	0.60
NLRP1	activates	gene	0.60
NLRP2	activates	gene	0.60
GAIN	implicated_in	gene	0.60
PTEN	activates	gene	0.60
GAIN	activates	gene	0.60
CARD8	activates	gene	0.60
TLR4	regulates	gene	0.60
CASP4	associated_with	gene	0.60
NLRP7	activates	gene	0.60
CASP6	associated_with	gene	0.60
BAX	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
TLR9	regulates	gene	0.60
NLRP7	associated_with	gene	0.60
AIM2	interacts_with	gene	0.60
CARD8	associated_with	gene	0.60
NLRP12	associated_with	gene	0.60
NLRP1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
NLRP3	regulates	gene	0.60
TNF	regulates	gene	0.60
BAX	expressed_in	gene	0.60
CASP4	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
NLRP10	activates	gene	0.60
NLRP10	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
RNA	activates	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
AGING	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
IL-18	regulates	gene	0.60
PER	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AND	activates	gene	0.60
IL-18	interacts_with	gene	0.60
NLR	activates	gene	0.60
NLRP3	co_discussed	protein	0.50
NLRP12	activates	gene	0.50
PYCARD	expressed_in	gene	0.50
CASP6	expressed_in	gene	0.50
NLRP2	co_expressed_with	gene	0.50
NLRP3	co_expressed_with	protein	0.50
DEMENTIA	activates	gene	0.50
GENES	regulates	gene	0.50
WAS	expressed_in	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NLRP6

Understanding Entity Pages

Summary

Wiki Pages (10)

NLRP6 - NLR Family Pyrin Domain Containing 6

NLRP3 Inflammasome Inhibitors for Parkinson's Disease

NLRP7 — NLR Family Pyrin Domain Containing 7

NLRP2 — NLR Family Pyrin Domain Containing 2

NLRP6 Protein (NACHT, LRR and PYD Domains-Containing Protein 6)

NLRP6 Protein - Inflammasome Component

IL4 Gene

NLRP12 — NLR Family Pyrin Domain Containing 12