FBXO7 Protein (PARK15)

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FBXO7 Protein (PARK15)

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wiki page Created: 2026-04-02T07:19:12 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-proteins-fbxo7

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FBXO7 — F-box Only Protein 7

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">FBXO7 Protein (PARK15)</th>
</tr>
<tr>
<td class="label">Substrate</td>
<td>Function</td>
</tr>
<tr>
<td class="label">Mitochondrial proteins</td>
<td>Quality control</td>
</tr>
<tr>
<td class="label">Cyclin E</td>
<td>Cell cycle</td>
</tr>
<tr>
<td class="label">BIN1</td>
<td>Cytoskeleton</td>
</tr>
<tr>
<td class="label">VDAC</td>
<td>Mitochondria</td>
</tr>
<tr>
<td class="label">Method</td>
<td>Application</td>
</tr>
<tr>
<td class="label">Co-IP</td>
<td>Complex identification</td>
</tr>
<tr>
<td class="label">Y2H</td>
<td>Binary interactions</td>
</tr>
<tr>
<td class="label">Mass spec</td>
<td>Global interactome</td>
</tr>
<tr>
<td class="label">BioID</td>
<td>Proximity labeling</td>
</tr>
<tr>
<td class="label">Partner</td>
<td>Interaction Type</td>
</tr>
<tr>
<td class="label">Skp1</td>
<td>Direct binding</td>
</tr>
<tr>
<td class="label">Cul1</td>
<td>Indirect</td>
</tr>
<tr>
<td class="label">ROC1</td>
<td>Indirect</td>
</tr>
<tr>
<td class="label">Parkin</td>
<td>Functional</td>
</tr>
<tr>
<td class="label">PINK1</td>
<td>Functional</td>
</tr>
<tr>
<td class="label">ULK1</td>
<td>Direct</td>
</tr>
<tr>
<td class="label">VDAC1</td>
<td>Direct</td>
</tr>
<tr>
<td class="label">Mfn1/2</td>
<td>Direct</td>
</tr>
<tr>

...

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Related Entities

FBXO7

▸Metadataorigin_type: v1_polymorphic_backfill

slug	proteins-fbxo7
kg_node_id	FBXO7
entity_type	protein
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-2c249157b26d
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'proteins-fbxo7'}
_schema_version	1

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

65%

Debates

0

Incoming

13

Outgoing

28

0 supporting 0 contradicting 0 neutral

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Public annotations (0)Annotate on Hypothes.is →

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📗 Cite This Artifact

FBXO7 Protein (PARK15)

FBXO7 — F-box Only Protein 7

FBXO7 — F-box Only Protein 7

Overview

Gene and Protein

Structure

Function in Mitochondrial Quality Control

Mitophagy Regulation

Interaction with Parkin

FBXO7 in Parkinson's Disease

Genetics

Clinical Features

Neuropathology

Molecular Mechanisms

Ubiquitin Ligase Substrates

Signaling Pathways

Therapeutic Implications

Target Potential

Drug Development

FBXO7 in Other Neurodegenerative Diseases

Alzheimer's Disease

Amyotrophic Lateral SALS

FBXO7 and Synaptic Function

Presynaptic Terminals

Postsynaptic Density

FBXO7 Expression Patterns

Brain Regional Distribution

Cell Type Specificity

FBXO7 Post-Translational Modifications

Phosphorylation

Ubiquitination

Model Systems

Animal Models

Cell Models

Biomarkers

FBXO7 as Biomarker

Research Methods

Protein-Protein Interactions

Future Directions

Key Questions

See Also

References

FBXO7 Structure-Function Relationships

F-Box Domain Analysis

Ubiquitin-Like (Ubl) Domain

FBXO7 Dimerization

FBXO7 in Cellular Homeostasis

Energy Metabolism

Redox Balance

Calcium Homeostasis

FBXO7 and Protein Quality Control

Substrate Recognition Motifs

Degradation Pathways

Aggregate Clearance

FBXO7 in Neurodevelopment

Neuronal Differentiation

Axonal Growth

Glial Development

FBXO7 in Aging

Age-Related Changes

Cellular Senescence

FBXO7 Pathogenic Mechanisms

Loss-of-Function

Gain-of-Function

FBXO7 Interactions Network

Protein-Protein Interaction Map

FBXO7 in Signaling Networks

FBXO7 Therapeutic Strategies

Gene Replacement

Small Molecule Modulators

Protein-Based Therapies

FBXO7 in Drug Development

High-Throughput Screening

Lead Compounds

Clinical Considerations

Patient Stratification

Outcome Measures

FBXO7 and Immune Function

Neuroinflammation