gene

FBXO7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FBXO7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

FBXO7 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with Als, Parkinson. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FBXO7
Full Name	F-Box Protein 7
Aliases	PARK15
Chromosome	22q12
Function	is a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex.
Molecular Weight	57 kDa
Amino Acids	524 aa
Pathways	mTOR, NF-κB, Wnt
GeneCards	FBXO7
Human Protein Atlas	FBXO7
Ubiquitin-Interacting Motifs (UIM)	Located in the C-terminal region, these motifs bind to monoubiquitin and polyubiquitin chains, facilitating substrate recognition and chain assembly[^10].
Proline-Rich Region	Mediates interactions with SH3 domain-containing proteins involved in signaling and cytoskeletal organization.
Dimerization Domain	Enables FBXO7 homodimerization, which may regulate its activity and substrate specificity[^11].
Nuclear Localization Signals (NLS)	FBXO7 contains both nuclear import and export signals, enabling nucleocytoplasmic shuttling.
Associated Diseases	ALS, Alzheimer, Cardiomyopathy, Cardiovascular, DOPAMINE
Interactions	MDM2, RPL23, USP7, PINK1, PLA2G6, PRKN
KG Connections	162 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FBXO7["FBXO7"]
    Parkinson{"Parkinson"}
    FBXO7 -->|"associated_with"| Parkinson
    Als{"Als"}
    FBXO7 -->|"activates"| Als
    Ms{"Ms"}
    FBXO7 -->|"therapeutic_target"| Ms
    FBXO7 -->|"therapeutic_target"| Als
    Cardiovascular{"Cardiovascular"}
    FBXO7 -->|"therapeutic_target"| Cardiovascular
    Inflammation{"Inflammation"}
    FBXO7 -->|"therapeutic_target"| Inflammation
    MDM2["MDM2"]
    FBXO7 -->|"activates"| MDM2
    GENES["GENES"]
    FBXO7 -->|"activates"| GENES
    RPL23["RPL23"]
    FBXO7 -->|"activates"| RPL23
    LYRM7["LYRM7"]
    FBXO7 -->|"associated_with"| LYRM7
    AND["AND"]
    FBXO7 -->|"associated_with"| AND
    BCS1L["BCS1L"]
    FBXO7 -->|"associated_with"| BCS1L
    INFLAMMATION["INFLAMMATION"]
    FBXO7 -->|"therapeutic_target"| INFLAMMATION
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated_with"| FBXO7
    TP53["TP53"]
    TP53 -->|"causes"| FBXO7

Outgoing (116)

Target	Relation	Type	Str
Septic Cardiomyopathy	biomarker_for	disease	0.85
PINK1	interacts_with	gene	0.80
PRKN	interacts_with	gene	0.80
SYNJ1	interacts_with	gene	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Parkinson's disease	activates	disease	0.80
VPS13C	interacts_with	gene	0.70
GBA1	interacts_with	gene	0.70
LRRK2	interacts_with	gene	0.70
PARK7	interacts_with	gene	0.70
SNCA	interacts_with	gene	0.70
autophagy pathway	participates_in	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy	co_discussed	concept	0.65
PARK7	co_discussed	gene	0.65
SNCA	co_discussed	gene	0.65
neurodegeneration	co_discussed	concept	0.65
LRRK2	co_discussed	gene	0.65
PINK1	co_discussed	gene	0.65
tau	co_discussed	concept	0.65
JNK	treats	gene	0.65
JNK	regulates	gene	0.65
UBIQUITIN	regulates	protein	0.65
PARKIN	activates	gene	0.65
Parkinson	associated_with	disease	0.65
Als	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiomyopathy	associated_with	disease	0.65
apoptosis	co_discussed	concept	0.65
APOPTOSIS	activates	phenotype	0.65
DOPAMINE	causes	phenotype	0.65
DOPAMINE	activates	phenotype	0.65
MDM2	activates	gene	0.60
RPL23	activates	gene	0.60
LYRM7	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
PLA2G6	associated_with	gene	0.60
PRKN	associated_with	gene	0.60

Incoming (46)

Source	Relation	Type	Str
ATP13A2	interacts_with	gene	0.80
DNAJC6	interacts_with	gene	0.80
ATP13A2	co_discussed	gene	0.65
AKT	co_discussed	gene	0.65
APOPTOSIS	protects_against	phenotype	0.65
TP53	causes	gene	0.60
TIMMDC1	associated_with	gene	0.60
CD14	therapeutic_target	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
LYRM7	associated_with	gene	0.60
CD14	associated_with	gene	0.60
BCS1L	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
DJ1	associated_with	gene	0.60
CHCHD2	activates	gene	0.60
CHCHD2	interacts_with	gene	0.60
AKT	activates	gene	0.60
CLPP	activates	gene	0.60
DJ1	interacts_with	gene	0.60
ATP13A2	expressed_in	gene	0.60
DJ1	expressed_in	gene	0.60
DNAJC6	expressed_in	gene	0.60
ATP1A3	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
P53	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
MRPS31	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
PGS1	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
LRRK2	implicated_in	gene	0.55
UNFOLDED PROTEIN RESPONSE	associated_with	pathway	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FBXO7

Understanding Entity Pages

Summary

Wiki Pages (21)

FBXO7 — F-Box Protein 7

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Multiple System Atrophy

Alzheimer's Disease

Gene-Mechanism-Therapy Causal Chains

proteasome-ubiquitin-system-dysfunction-parkinsons

ubiquitin-proteasome-dysfunction-neurodegeneration

Shy-Drager Syndrome

Shy-Drager Syndrome

ATP13A2 — ATPase Cation Transporting 13A2

Ubiquitin-Proteasome System Dysfunction in Neurodegeneration

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

FBXO7 Protein (PARK15)

PARK19 (DNAJC6-Related Parkinson's Disease)

Dopaminergic Neurodegeneration

Alpha-Synuclein (α-Synuclein)

Proteasomal Pathway in Neurodegeneration

Diseases Quality Rankings