protein 2,779 words KG: FBXO7 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

FBXO7 Protein (PARK15)

🔬 Protein Info
Gene SymbolFBXO7
Full NameF-box Only Protein 7
AliasesPARK15
Chromosome22q12
Functionis a substrate recognition component of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex.
Molecular Weight57 kDa
Amino Acids524 aa
PathwaysmTOR, NF-κB, Wnt
GeneCardsFBXO7
Human Protein AtlasFBXO7
Mitochondrial proteinsQuality control
Cyclin ECell cycle
BIN1Direct
VDACMitochondria
MethodApplication
Associated DiseasesALS, Alzheimer, Cardiomyopathy, Cardiovascular, DOPAMINE
InteractionsMDM2, RPL23, USP7, PINK1, PLA2G6, PRKN
KG Connections162 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Circadian Clock-Autophagy Synchronization
Score: 0.55
Temporal Decoupling via Circadian Clock Reset
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target
DNAJC13 — DnaJ Heat Shock Protein Family Member C13
gene · KG edge: associated_with
CD14 — CD14 Molecule
gene · KG edge: associated_with

Knowledge Graph (12 edges)

FBXO7 activates MDM2
FBXO7 activates RPL23
FBXO7 associated_with LYRM7
FBXO7 associated_with BCS1L
FBXO7 biomarker_for Septic Cardiomyopathy
FBXO7 associated_with PINK1
FBXO7 associated_with VPS13C
FBXO7 associated_with DNAJC6
FBXO7 associated_with ATP13A2
FBXO7 associated_with PLA2G6