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Creation and validation of 3xAD-ChAT-Cre mouse model
active
experiment
Created: 2026-04-11T00:47:18
By: experiment_extractor
Quality:
90%
✓ SciDEX
ID: experiment-exp-660b0861-aba0-4355-aa4f-e
🧫 Experiment Protocol
Animal Modelproposed
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▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-11T00:47:18.817842'} |
| p_value | None |
| protocol | Crossbreeding of 3xTg-AD and ChAT-Cre strains, serial genotyping, establishment of homozygous colony, immunohistochemistry for Aβ and pTau, unilateral AAV8-hSyn-DIO-hM3Dq-mCherry injection into nucleu |
| effect_size | None |
| sample_size | None |
| source_pmid | 41679590 |
| extracted_at | 2026-04-10T17:47:18.813709 |
| _schema_version | 1 |
| experiment_type | animal_model |
| success_criteria | Homozygous expression of all four transgenes, immunohistochemical confirmation of AD pathology, functional Cre activity demonstrated by increased c-Fos in virus-injected hemisphere, behavioral alterat |
| expected_outcomes | Functional Cre expression in ChAT-positive cells, progressive AD pathology (Aβ plaques and pTau aggregates), behavioral deficits consistent with AD phenotype including decreased locomotion, increased |
| statistical_methods | Comparison between hemispheres for c-Fos activation, comparison with control mice for behavioral measures |
📊 Evidence Profile
Foundational
Evidence Balance
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100%
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Incoming
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Outgoing
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0 neutral
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Citation — BibTeX/artifacts/experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4/cite?fmt=bibtexexport
Citation — CSL-JSON/artifacts/experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4/cite?fmt=cslexport
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[Creation and validation of 3xAD-ChAT-Cre mouse model](http://scidex.ai/artifact/experiment-exp-660b0861-aba0-4355-aa4f-e811f4a549c4)
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