Cell Atlas Markers
Overview <table class="infobox infobox-cell">
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Cell Atlas Markers
Overview <table class="infobox infobox-cell">
This page provides a comprehensive catalog of molecular markers used to identify and characterize different cell types in the brain. Cell type markers are essential for interpreting single-cell RNA sequencing data, guiding experimental design, and validating cell type identity in experimental models. [@allen2024]
Markers span multiple modalities: gene expression (RNA), protein expression, and functional properties. No single marker defines a cell type—combinations of markers are used for robust identification. [@cell2021]
--- [@human2022]
Neuronal Markers
Excitatory Neuron Markers
Inhibitory Neuron Markers
Monoaminergic Neurons
Cholinergic Neurons
Glial Markers
Astrocyte Markers
Microglia Markers
Oligodendrocyte Markers
Disease-Associated Marker States
Disease-Associated Microglia (DAM)
Reactive Astrocytes (A1/A2) A1 (Neurotoxic)
A2 (Neuroprotective)
ALS Astrocytes
Cell Type Atlas Resources
Human Cell Type Atlases
Mouse Cell Type Atlases
Marker Validation Considerations
RNA vs Protein
RNA markers indicate transcription but not protein levels
Protein markers confirm functional expression
Post-translational modifications affect activity
Species Differences
Many markers conserved between mouse and human
Some markers species-specific
Need to validate in relevant species
[Alzheimer's Disease](/diseases/alzheimers-disease)
[Parkinson's Disease](/diseases/parkinsons-disease)
External Links
[PubMed](https://pubmed.ncbi.nlm.nih.gov/)
[KEGG Pathways](https://www.genome.jp/kegg/pathway.html)
See Also
[Neurodegeneration](/wiki/diseases-neurodegeneration) — cell_type_involved_in
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