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Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.
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ID: paper-33542149
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Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.
["Li T", "Huang T", "Du M", "Chen X", "Du F", "Ren J", "Chen Z"]
Abstract
The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) detects microbial and self-DNA in the cytosol to activate immune and inflammatory programs. cGAS also associates with chromatin, especially after nuclear envelope breakdown when cells enter mitosis. How cGAS is regulated during cell cycle transition is not clear. Here, we found direct biochemical evidence that cGAS activity was selectively suppressed during mitosis in human cell lines and uncovered two paralle...
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