📄
CRISPR-engineered human lung organoids with a biomolecular condensate reporter enable mechanistic toxicity monitoring.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-41809383
📄 Paper Details
CRISPR-engineered human lung organoids with a biomolecular condensate reporter enable mechanistic toxicity monitoring.
["Kim S", "Baek J", "Kim E", "Srinivasan S", "Kim K", "Kim E"]
Abstract
Understanding how chemical stress perturbs human lung physiology requires models that capture dynamic molecular responses in real time. Here, we established a CRISPR/Cas9-engineered human induced pluripotent stem cell (hiPSC)-derived lung organoid expressing endogenous G3BP1-mCherry, enabling live, non-destructive visualization of stress granule (SG) formation under toxicant exposure. The organoids recapitulated airway and alveolar epithelial diversity and displayed lamellar body-like ultrastruc...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.