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Alirocumab Attenuated Plaque Inflammation and PCSK9-Induced Proinflammatory Signalling in M1 Macrophages Independently of Lipid Lowering.
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ID: paper-41897333
📄 Paper Details
Alirocumab Attenuated Plaque Inflammation and PCSK9-Induced Proinflammatory Signalling in M1 Macrophages Independently of Lipid Lowering.
Espadas C, Soto-Catalán M, Romero-Cote M, Kavanagh M, Herrero-Del Real I, Ortega-Hernández A, Lumpuy-Castillo J, Gómez-Garre D, Egido J, Tuñón J, Gómez-Guerrero C, Lorenzo Ó
Abstract
BACKGROUND: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) has been implicated in vascular inflammation beyond its action on LDL-C degradation. We investigated whether PCSK9 may exacerbate proinflammatory signaling of M1 macrophages and if its neutralization with alirocumab could attenuate this effect and plaque progression by LDL-C independent mechanisms. METHODS: ApoE-/- mice were treated with alirocumab for 13 weeks, and aortic arches were isolated for atherosclerotic plaque characteri...
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📊 Evidence Profile
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+0%
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