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Cathelicidin Links Visceral Fat Accumulation and Coronary Artery Disease.

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paper Created: By: unknown Quality: 50% ✓ SciDEX ID: paper-41905956
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Cathelicidin Links Visceral Fat Accumulation and Coronary Artery Disease.
Taniguchi M, Taruya A, Kitahara C, Ota S, Kato T, Desaki Y, Sasaki I, Katayama Y, Wada T, Takahata M, Satogami K, Ozaki Y, Kashiwagi M, Shiono Y, Honda K, Yamano T, Takemoto K, Kuroi A, Kitabata H, He
Circulation journal : official journal of the Japanese Circulation Society PubMed DOI
Abstract

BACKGROUND: Visceral fat (VF), particularly epicardial adipose tissue (EAT), plays a crucial role in the development of coronary artery disease (CAD). Cathelicidin (LL37) is an antimicrobial peptide involved in innate immunity and has been implicated in inflammatory processes. However, the relationship between VF accumulation, cathelicidin, and atherosclerosis remains unclear. METHODS AND RESULTS: Seventy-eight subjects without CAD were enrolled and classified by obesity type: normal-weight (nor...

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