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Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice.
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ID: paper-41916957
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Astrocytic APOE3-Christchurch expression ameliorates brain amyloid-β pathology in 5xFAD mice.
Raulin AC, Alnobani A, Rodriguez-Martinez P, Lee E, Linares C, Yslas AR, Li M, Ren Y, Doss SV, Roy B, Kuchenbecker LA, Martens YA, Liu CC, Bu G, Kanekiyo T
Abstract
The rare APOE3-Christchurch (APOE3Ch) variant is linked to resistance against PSEN1 p.E280A-driven autosomal dominant Alzheimer's disease (AD). Recent studies in AD mouse models have demonstrated an effect of APOE3Ch in reducing tau pathology and tau propagation, yet its effects on amyloid pathology and related toxicity are not fully understood. While prior studies have reported reduced amyloid pathology with APOE3Ch, we extended this knowledge by investigating how astrocyte-specific expression ...
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