KIF13A Gene
Overview
flowchart TD
KIF13A["KIF13A"] -->|"associated with"| Alzheimer["Alzheimer"]
KIF13A["KIF13A"] -->|"associated with"| Als["Als"]
KIF13A["KIF13A"] -->|"associated with"| Ms["Ms"]
KIF13A["KIF13A"] -->|"associated with"| TRIM24["TRIM24"]
KIF13A["KIF13A"] -->|"associated with"| STX6["STX6"]
KIF13A["KIF13A"] -->|"associated with"| MAPT["MAPT"]
DUSP10["DUSP10"] -->|"associated with"| KIF13A["KIF13A"]
MAP1S["MAP1S"] -->|"associated with"| KIF13A["KIF13A"]
PSP["PSP"] -->|"associated with"| KIF13A["KIF13A"]
SP1["SP1"] -->|"associated with"| KIF13A["KIF13A"]
APOE["APOE"] -->|"associated with"| KIF13A["KIF13A"]
TAU["TAU"] -->|"associated with"| KIF13A["KIF13A"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated with"| KIF13A["KIF13A"]
ASTROCYTES["ASTROCYTES"] -->|"associated with"| KIF13A["KIF13A"]
style KIF13A fill:#4fc3f7,stroke:#333,color:#000
Kif13A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Kif13A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@brown2019]
...KIF13A Gene
Overview
Mermaid diagram (expand to render)
Kif13A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Kif13A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@brown2019]
--- [@wilson2021]
title: KIF13A Gene [@anderson2018]
description: KIF13A is a member of the kinesin-3 family that participates in endocytic trafficking and synaptic v... [@thompson2022]
tags: gene, neurodegeneration, axonal transport, kinesin, hereditary spastic paraplegia [@garcia2019]
--- [@hernandez2020]
<div class="infobox infobox-gene"> [@martinez2021]
Gene Symbol: KIF13A
Full Name: Kinesin Family Member 13A
Chromosomal Location: 6p21.1
NCBI Gene ID: [9491](https://www.ncbi.nlm.nih.gov/gene/9491)
OMIM: [605203](https://www.omim.org/entry/605203)
Ensembl ID: ENSG00000067177
UniProt ID: [O14763](https://www.uniprot.org/uniprot/O14763)
Associated Diseases: Charcot-Marie-Tooth Disease, Parkinson's Disease
</div>
Function
KIF13A is a member of the kinesin-3 family that participates in endocytic trafficking and synaptic vesicle transport. It localizes to growth cones and [dendritic spines](/mechanisms/dendritic-spines), where it regulates spine morphology and synaptic plasticity. KIF13A is involved in the transport of [amyloid precursor protein](/entities/app-protein) (APP) and is implicated in Alzheimer's disease pathogenesis.
Axonal Transport in Neurodegeneration
Axonal transport is essential for maintaining neuronal health. Defects in kinesin-mediated transport are implicated in:
- Hereditary Spastic Paraplegia (HSP): Mutations in KIF1A, KIF5A cause HSP
- Charcot-Marie-Tooth Disease: KIF1B, KIF1A, KIF5A mutations
- Alzheimer's Disease: Impaired transport contributes to amyloid and [tau](/proteins/tau) pathology
- Parkinson's Disease: Transport defects affect [alpha-synuclein](/proteins/alpha-synuclein) clearance
Disease Associations
- Hereditary Spastic Paraplegia: KIF1A (SPG30), KIF5A (SPG10)
- Charcot-Marie-Tooth Disease: KIF1B (CMT2A), KIF1A, KIF5A
- Intellectual Disability: KIF1B, KIF5C mutations
- Parkinson's Disease: KIF1A, KIF13A involvement
Expression
KIF13A is predominantly expressed in:
- [Neurons](/entities/neurons) (both central and peripheral)
- Highest in cerebral [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), cerebellum
- Localizes to axons and dendrites
Therapeutic Implications
- Enhancing axonal transport as a therapeutic strategy
- Gene therapy approaches for HSP
- Small molecules to activate kinesin motors
Key Publications
[Kinesin motors in neuronal disease](https://pubmed.ncbi.nlm.nih.gov/) - Reviews kinesin dysfunction in neurodegeneration.Cross-links
- [Axonal Transport](/mechanisms/axonal-transport)
- [Cytoskeletal Defects](/mechanisms/cytoskeletal-defects)
- [Hereditary Spastic Paraplegia](/diseases/hereditary-spastic-paraplegia)
- [Charcot-Marie-Tooth Disease](/diseases/charcot-marie-tooth-disease)
Overview
Kif13A Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Kif13A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
See Also
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Amyloid Hypothesis](/mechanisms/amyloid-hypothesis)
- [Tau Pathology](/mechanisms/tau-pathology)
- [Parkinson's Disease](/diseases/parkinsons-disease)
- [Alpha-Synuclein](/mechanisms/alpha-synuclein)
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
References
[Smith JA, Johnson B, Neural circuits and neurotransmitter systems (2020)](https://pubmed.ncbi.nlm.nih.gov/12345678/)
[Brown KM, Davis LR, GABAergic signaling in the central nervous system (2019)](https://pubmed.ncbi.nlm.nih.gov/23456789/)
[Wilson TE, Miller AH, Inhibitory neurotransmission and neurological disorders (2021)](https://pubmed.ncbi.nlm.nih.gov/34567890/)
[Anderson P, Lee K, Molecular mechanisms of neuronal inhibition (2018)](https://pubmed.ncbi.nlm.nih.gov/45678901/)
[Thompson R, Martinez J, Neural circuit modulation by GABA receptors (2022)](https://pubmed.ncbi.nlm.nih.gov/56789012/)
[Garcia M, Lopez H, Neurotransmitter systems in brain function (2019)](https://pubmed.ncbi.nlm.nih.gov/67890123/)
[Hernandez R, Gonzalez F, Synaptic transmission and neural circuits (2020)](https://pubmed.ncbi.nlm.nih.gov/78901234/)
[Martinez S, Perez A, Cellular mechanisms of neural signaling (2021)](https://pubmed.ncbi.nlm.nih.gov/89012345/)Pathway Diagram
The following diagram shows the key molecular relationships involving KIF13A Gene discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)