gene 560 words KG: KIF13A 2026-03-24
kind:genesection:genesstate:published
Contents

KIF13A Gene

🧬 Gene Info
Gene SymbolKIF13A
Chromosome6p21.1
FunctionKIF13A is a member of the kinesin-3 family that participates in endocytic trafficking and synaptic vesicle transport.
Molecular Weight189 kDa
UniProt IDO14763
NCBI Gene ID9491
Ensembl IDENSG00000067177
GeneCardsKIF13A
Human Protein AtlasKIF13A
Hereditary Spastic Paraplegia (HSP)Mutations in KIF1A, KIF5A cause HSP
Charcot-Marie-Tooth DiseaseKIF1B (CMT2A), KIF1A, KIF5A
Alzheimer's DiseaseImpaired transport contributes to amyloid and tau pathology
Parkinson's DiseaseKIF1A, KIF13A involvement
Hereditary Spastic ParaplegiaKIF1A (SPG30), KIF5A (SPG10)
Intellectual DisabilityKIF1B, KIF5C mutations
Associated DiseasesAls, Alzheimer, Ms
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (5)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Tau Protein
protein · KG edge: associated_with
Tau Consortium
organization · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

KIF13A associated_with TRIM24
KIF13A associated_with STX6
KIF13A associated_with MAPT
KIF13A associated_with Alzheimer
KIF13A associated_with Als
KIF13A associated_with Ms
DUSP10 associated_with KIF13A
MAP1S associated_with KIF13A
PSP associated_with KIF13A
SP1 associated_with KIF13A