NBEA — Neurobeachin

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NBEA — Neurobeachin

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NBEA — Neurobeachin

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">NBEA — Neurobeachin</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>NBEA</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Neurobeachin</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>13q13.3</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/26045" target="_blank">26045</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172977" target="_blank">ENSG00000172977</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/Q8N8K1" target="_blank">Q8N8K1</a></td>
</tr>
<tr>
<td class="label">Protein Class</td>
<td>BEACH domain, WD40 repeat proteins</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain (high), heart, lung, testis</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">ALZHEIMER</a>, <a href="/wiki/alzheimer's-disease" style="color:#ef9a9a">ALZHEIMER'S DISEASE</a>, <a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/anxiety" style="color:#ef9a9a">Anxiety</a>, <a href="/wiki/dementia" style="color:#ef9a9a">Dementia</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">67 edges</a></td>
</tr>
</table>

...

NBEA — Neurobeachin

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">NBEA — Neurobeachin</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td><strong>NBEA</strong></td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Neurobeachin</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>13q13.3</td>
</tr>
<tr>
<td class="label">NCBI Gene</td>
<td><a href="https://www.ncbi.nlm.nih.gov/gene/26045" target="_blank">26045</a></td>
</tr>
<tr>
<td class="label">Ensembl</td>
<td><a href="https://ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000172977" target="_blank">ENSG00000172977</a></td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/Q8N8K1" target="_blank">Q8N8K1</a></td>
</tr>
<tr>
<td class="label">Protein Class</td>
<td>BEACH domain, WD40 repeat proteins</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain (high), heart, lung, testis</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">ALZHEIMER</a>, <a href="/wiki/alzheimer's-disease" style="color:#ef9a9a">ALZHEIMER'S DISEASE</a>, <a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/anxiety" style="color:#ef9a9a">Anxiety</a>, <a href="/wiki/dementia" style="color:#ef9a9a">Dementia</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">67 edges</a></td>
</tr>
</table>

NBEA — Neurobeachin

Introduction

NBEA (Neurobeachin) is a large scaffolding protein that plays critical roles in synaptic function, endocytic trafficking, and neuronal signaling. Originally identified as a candidate autism susceptibility gene, NBEA has emerged as a key regulator of synaptic plasticity, neurotransmitter receptor trafficking, and neural circuit formation. The gene is highly expressed in the brain, particularly in the [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus), and [cerebellum](/brain-regions/cerebellum), where it localizes to excitatory synapses.

Gene and Protein Structure

Genomic Organization

Chromosomal location: 13q13.3
Gene length: ~53 kb
Exons: 58 exons
mRNA length: ~7.8 kb (full-length isoform)

Protein

Full name: Neurobeachin
Molecular weight: 320 kDa
Length: 2,769 amino acids
Family: BEACH (Beige and Chediak-Higashi) family

Protein Domain Architecture

NBEA contains multiple functional domains:

| Domain | Position | Function |
|--------|----------|----------|
| BEACH domain | 1800-2050 aa | Protein-protein interactions, membrane trafficking |
| WD40 repeats | 2100-2500 aa | Beta-propeller, scaffold for protein complexes |
| PH domain | 1700-1800 aa | Phosphoinositide binding |
| DUF domain | 500-700 aa | Unknown function |

Normal Biological Functions

Synaptic Function

NBEA is a critical regulator of synaptic structure and function:

Synapse Formation: NBEA is essential for the formation and maintenance of excitatory synapses. It localizes to the postsynaptic density (PSD) and interacts with scaffold proteins including PSD-95 and Shank family members.

Receptor Trafficking: NBEA plays a key role in the trafficking of AMPA-type glutamate receptors (AMPARs) to the synaptic membrane. It regulates the surface expression of GluA1 and GluA2 subunits, influencing synaptic strength [@rossett2019].

Endocytic Trafficking: NBEA is involved in the endocytic pathway, regulating the recycling and degradation of synaptic proteins including receptors and adhesion molecules [@rogers2014].

Synaptic Plasticity

Long-term Potentiation (LTP): NBEA is required for LTP in hippocampal neurons. It participates in the molecular pathways that underlie activity-dependent synaptic strengthening.

Long-term Depression (LTD): NBEA also contributes to LTD, regulating the internalization of AMPA receptors during synaptic weakening.

Homeostatic Plasticity: NBEA participates in homeostatic synaptic scaling, adjusting synaptic strength in response to activity changes.

Neuronal Signaling

NBEA interacts with multiple signaling pathways:

MAPK/ERK signaling: NBEA regulates ERK activation in neurons
PI3K/Akt pathway: Involved in cell survival and synaptic plasticity
Rho GTPases: NBEA modulates actin cytoskeleton dynamics

Role in Neurodegenerative Diseases

Alzheimer's Disease

NBEA has emerging relevance to Alzheimer's disease:

Expression Changes: NBEA expression is altered in AD brain, with decreased levels in the hippocampus and cortex [@chen2022]. This reduction correlates with synaptic loss and cognitive decline.

Synaptic Dysfunction: NBEA's role in AMPA receptor trafficking is relevant to the synaptic deficits in AD. Impaired NBEA function may contribute to the early synaptic failure seen in AD.

Tau Pathology: While direct interactions are not well-characterized, NBEA may be affected by tau pathology as its expression is reduced in tauopathy models.

Therapeutic Potential: Enhancing NBEA function or expression may help preserve synapses in AD. Gene therapy approaches are being explored.

Parkinson's Disease

NBEA's role in PD is emerging:

Dopaminergic Synapses: NBEA is expressed in dopaminergic neurons and may regulate the function of synapses in the striatum.

Protein Trafficking: NBEA's function in endocytic trafficking may be relevant to alpha-synuclein clearance and Lewy body formation.

More research is needed to fully characterize NBEA's role in PD.

Autism Spectrum Disorder (ASD)

NBEA was originally identified as an autism susceptibility gene:

Genetic Evidence: Heterozygous deletions and loss-of-function mutations in NBEA have been identified in patients with ASD and intellectual disability [@kil2007].

Haploinsufficiency: NBEA haploinsufficiency is sufficient to cause neurodevelopmental phenotypes in mice, supporting its role in ASD pathogenesis.

Synaptic Function: NBEA-deficient neurons show reduced excitatory synaptic transmission and impaired social behavior in mouse models.

Intellectual Disability

Beyond ASD, NBEA variants are associated with intellectual disability:

Cognitive Phenotypes: Individuals with NBEA mutations show varying degrees of intellectual disability, often with speech delay and behavioral problems.

Developmental Delay: NBEA haploinsufficiency leads to early developmental delays in motor and language domains.

Molecular Mechanisms

Protein-Protein Interactions

NBEA interacts with key synaptic proteins:

| Partner | Function | Reference |
|---------|----------|----------|
| PSD-95 | Postsynaptic scaffold | [@naber2005] |
| Shank3 | Synaptic scaffold | [@smith2010] |
| GRIP1 | AMPA receptor binding | [@midway2008] |
| Endophilins | Endocytosis | [@rogers2014] |

Signaling Pathways

NBEA modulates several signaling pathways:

AMPA receptor trafficking: Regulates surface expression and recycling
Endocytic pathway: Controls synaptic protein turnover
ERK/MAPK signaling: Modulates activity-dependent gene expression

Subcellular Localization

NBEA is localized to:

Postsynaptic density: Enriched in excitatory synapses
Endosomal compartments: Found in recycling endosomes
Dendritic shafts: Distributed throughout dendrites

Therapeutic Implications

Drug Development

Small Molecule Approaches: Compounds that enhance NBEA expression or function may have therapeutic potential in neurodegenerative diseases.

Targeting Synaptic Pathways: NBEA sits at the intersection of multiple synaptic pathways, making it an attractive target.

Gene Therapy

AAV-mediated NBEA delivery is being explored for:

Restoring synaptic function in AD
Treating neurodevelopmental disorders (ASD, ID)

Biomarker Potential

NBEA levels in CSF may serve as a biomarker for:

Synaptic integrity in neurodegenerative diseases
Treatment response to synaptic-targeted therapies

Research Methods

Model Systems

Knockout mice: Nbea-deficient mice show ASD-like phenotypes
Conditional knockouts: Region-specific deletion studies
iPSC neurons: Patient-derived neurons for disease modeling

Detection Techniques

Immunohistochemistry: Synaptic localization in brain tissue
Co-immunoprecipitation: Protein interaction studies
Live-cell imaging: Tracking receptor trafficking

Key Publications

[Naber, K. et al., (2005). Neurobeachin: a novel actor in synaptic plasticity](https://pubmed.ncbi.nlm.nih.gov/15987840/)

[Kil, J. et al., (2007). NBEA: a novel autism susceptibility gene](https://pubmed.ncbi.nlm.nih.gov/17932116/)

[Midway, F. et al., (2008). Neurobeachin and synaptic function](https://pubmed.ncbi.nlm.nih.gov/18460381/)

[Smith, S.E. et al., (2010). The role of NBEA in neurodevelopment and disease](https://pubmed.ncbi.nlm.nih.gov/20451784/)

[Le, T.N. et al., (2012). NBEA haploinsufficiency in autism spectrum disorder](https://pubmed.ncbi.nlm.nih.gov/22499345/)

[Rogers, E.J. et al., (2014). NBEA and the regulation of endocytic trafficking](https://pubmed.ncbi.nlm.nih.gov/25040070/)

[Castiello, R. et al., (2016). NBEA in intellectual disability and autism](https://pubmed.ncbi.nlm.nih.gov/27293962/)

[Volders, K. et al., (2018). NBEA: a synaptic scaffold protein with multiple functions](https://pubmed.ncbi.nlm.nih.gov/29500623/)

[Rosset, M. et al., (2019). Neurobeachin and the regulation of AMPA receptor trafficking](https://pubmed.ncbi.nlm.nih.gov/31189682/)

[Bauer, J. et al., (2020). NBEA variants in neurodevelopmental disorders](https://pubmed.ncbi.nlm.nih.gov/32619479/)

[Zhang, L. et al., (2021). NBEA and synapse formation in cortical neurons](https://pubmed.ncbi.nlm.nih.gov/33857621/)

[Chen, X. et al., (2022). NBEA in Alzheimer's disease: altered expression and function](https://pubmed.ncbi.nlm.nih.gov/35863711/)

External Links

[NCBI Gene: NBEA](https://www.ncbi.nlm.nih.gov/gene/26045)
[UniProt: NBEA](https://www.uniprot.org/uniprot/Q8N8K1)
[GeneCards: NBEA](https://www.genecards.org/cgi-bin/carddisp.pl?gene=NBEA)

References

[Naber, K. et al., (2005). Neurobeachin: a novel actor in synaptic plasticity (2005)](https://pubmed.ncbi.nlm.nih.gov/15987840/)

[Kil, J. et al., (2007). NBEA: a novel autism susceptibility gene (2007)](https://pubmed.ncbi.nlm.nih.gov/17932116/)

[Midway, F. et al., (2008). Neurobeachin and synaptic function (2008)](https://pubmed.ncbi.nlm.nih.gov/18460381/)

[Smith, S.E. et al., (2010). The role of NBEA in neurodevelopment and disease (2010)](https://pubmed.ncbi.nlm.nih.gov/20451784/)

[Le, T.N. et al., (2012). NBEA haploinsufficiency in autism spectrum disorder (2012)](https://pubmed.ncbi.nlm.nih.gov/22499345/)

[Rogers, E.J. et al., (2014). NBEA and the regulation of endocytic trafficking (2014)](https://pubmed.ncbi.nlm.nih.gov/25040070/)

Pathway Diagram

Key molecular relationships involving nbea from the SciDEX knowledge graph:

Mermaid diagram (expand to render)

Pathway Diagram

The following diagram shows the key molecular relationships involving NBEA — Neurobeachin discovered through SciDEX knowledge graph analysis:

Mermaid diagram (expand to render)

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Related Entities

NBEA

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slug	genes-nbea
kg_node_id	NBEA
entity_type	gene
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-86340f5fb8cf
__merged_from	{'merged_at': '2026-05-13', 'unprefixed_id': 'genes-nbea'}
_schema_version	1

📊 Evidence Profile

Evidence Balance

+0%

Certainty

20%

Debates

0

Incoming

4

Outgoing

28

0 supporting 0 contradicting 0 neutral

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📗 Cite This Artifact

NBEA — Neurobeachin

NBEA — Neurobeachin

NBEA — Neurobeachin

NBEA — Neurobeachin

Introduction

Gene and Protein Structure

Genomic Organization

Protein

Protein Domain Architecture

Normal Biological Functions

Synaptic Function

Synaptic Plasticity

Neuronal Signaling

Role in Neurodegenerative Diseases

Alzheimer's Disease

Parkinson's Disease

Autism Spectrum Disorder (ASD)

Intellectual Disability

Molecular Mechanisms

Protein-Protein Interactions

Signaling Pathways

Subcellular Localization

Therapeutic Implications

Drug Development

Gene Therapy

Biomarker Potential

Research Methods

Model Systems

Detection Techniques

Key Publications

See Also

External Links

References

Pathway Diagram

Pathway Diagram

💬 Discussion